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Chen-Yang Shen
Researcher at Academia Sinica
Publications - 168
Citations - 19120
Chen-Yang Shen is an academic researcher from Academia Sinica. The author has contributed to research in topics: Breast cancer & Single-nucleotide polymorphism. The author has an hindex of 57, co-authored 166 publications receiving 17287 citations. Previous affiliations of Chen-Yang Shen include University of Hamburg & China Medical University (PRC).
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Journal ArticleDOI
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium
Roger L. Milne,Roger L. Milne,Barbara Burwinkel,Kyriaki Michailidou,Jose-Ignacio Arias-Perez,M. Pilar Zamora,Primitiva Menendez-Rodriguez,David Hardisson,Marta Mendiola,Anna González-Neira,Guillermo Pita,M. Rosario Alonso,Joe Dennis,Qin Wang,Manjeet K. Bolla,Anthony J. Swerdlow,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Yon-Dschun Ko,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Sandrine Tchatchou,kConFab Investigators,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Jingmei Li,Judith S. Brand,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Diether Lambrechts,Gilian Peuteman,Marie-Rose Christiaens,Ann Smeets,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katazyna Durda,Mikael Hartman,Miao Hui,Wei-Yen Lim,Ching Wan Chan,Federick Marme,Rongxi Yang,Peter Bugert,Annika Lindblom,Sara Margolin,Montserrat Garcia-Closas,Stephen J. Chanock,Jolanta Lissowska,Jonine D. Figueroa,Stig E. Bojesen,Stig E. Bojesen,Børge G. Nordestgaard,Børge G. Nordestgaard,Henrik Flyger,Maartje J. Hooning,Mieke Kriege,Ans M.W. van den Ouweland,Linetta B. Koppert,Olivia Fletcher,Nichola Johnson,Isabel dos-Santos-Silva,Julian Peto,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Marjanka K. Schmidt,Annegien Broeks,Sten Cornelissen,Linde M. Braaf,Daehee Kang,Ji Yeob Choi,Sue K. Park,Dong-Young Noh,Jacques Simard,Martine Dumont,Mark S. Goldberg,Mark S. Goldberg,Peter A. Fasching,Alexander Hein,Arif B. Ekici,Matthias W. Beckmann,Paolo Radice,Paolo Peterlongo,Jacopo Azzollini,Monica Barile,Elinor J. Sawyer,Ian Tomlinson,Ian Tomlinson,Michael J. Kerin,Nicola Miller,John L. Hopper,Daniel F. Schmidt,Enes Makalic,Melissa C. Southey,Soo Hwang Teo,Cheng Har Yip,Kavitta Sivanandan,Wan Ting Tay,Chen-Yang Shen,Chen-Yang Shen,Chia-Ni Hsiung,Jyh-Cherng Yu,Ming-Feng Hou,Pascal Guénel,Thérèse Truong,Marie Sanchez,Claire Mulot,William Blot,Qiuyin Cai,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Natalia Bogdanova,Thilo Dörk,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Ben Zhang,Fergus J. Couch,Amanda E. Toland,Tnbcc,Drakoulis Yannoukakos,Suleeporn Sangrajrang,James McKay,Xianshu Wang,Janet E. Olson,Celine M. Vachon,Kristen S. Purrington,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Kamila Czene,Mikael Eriksson,Keith Humphreys,Hatef Darabi,Shahana Ahmed,Mitul Shah,Paul D.P. Pharoah,Per Hall,Graham G. Giles,Graham G. Giles,Javier Benitez,Alison M. Dunning,Georgia Chenevix-Trench,Douglas F. Easton +190 more
TL;DR: A novel susceptibility locus at 3p21 is identified, and previous suggestive evidence that rs6964587 at 7q21 is associated with risk is confirmed, and further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.
Posted ContentDOI
Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM
Chang Liu,Y.Y. Yang,Yuanzhu Gao,Chen-Yang Shen,Ju B,Xulei Tang,Jun Wei,Xiaomin Ma,William J. Liu,Shuman Xu,Yan Jun Liu,Yuan J,Jinsong Wu,Zheng Liu,Zike Zhang,Peng George Wang,Liping Liu +16 more
TL;DR: The morphology of virion observed in the result indicates that the S protein of SARS-CoV-2 is in post-fusion state, with S1 disassociated, which could provide an important information for the identification and relevant clinical research of this new coronavirus.
Journal ArticleDOI
Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53 , in breast cancer is related to tumour grade
TL;DR: It is suggested that combined changes in several DSB checkpoint/repair genes belonging to a common functional pathway are associated with breast cancer pathogenesis.
Journal ArticleDOI
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility
Shian-ling Ding,Jyh-Cherng Yu,Shou-Tung Chen,Giu-Cheng Hsu,Shou-Jen Kuo,Yu Hsin Lin,Pei-Ei Wu,Chen-Yang Shen +7 more
TL;DR: A contribution of BLM and RAD51 to breast cancer development is suggested and support for the tumorigenic significance of the functional interaction between these two HR proteins is provided.
Journal ArticleDOI
The clinical implications of MMP-11 and CK-20 expression in human breast cancer
Chun-Wen Cheng,Jyh-Cherng Yu,Hsiao-Wei Wang,Chiun-Sheng Huang,Jia-Ching Shieh,Yi-Ping Fu,Chia-Wei Chang,Pei-Ei Wu,Chen-Yang Shen,Chen-Yang Shen +9 more
TL;DR: It is demonstrated that MMP-11 and CK-20 are probable prognostic markers whose expression reflects the stages of tumor differentiation and LNM of breast cancer.