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Claudia Jakubzick
Researcher at Dartmouth College
Publications - 88
Citations - 12902
Claudia Jakubzick is an academic researcher from Dartmouth College. The author has contributed to research in topics: Antigen & Macrophage. The author has an hindex of 42, co-authored 79 publications receiving 11045 citations. Previous affiliations of Claudia Jakubzick include Pennsylvania State University & University of Colorado Denver.
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Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Martin Guilliams,Florent Ginhoux,Claudia Jakubzick,Shalin H. Naik,Nobuyuki Onai,Barbara U. Schraml,Elodie Segura,Roxane Tussiwand,Simon Yona +8 more
TL;DR: This Opinion article suggests that the mononuclear phagocyte system can be classified primarily by their ontogeny and secondarily by their location, function and phenotype, which permits a more robust classification during both steady-state and inflammatory conditions.
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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Frank Tacke,David Alvarez,Theodore J. Kaplan,Claudia Jakubzick,Rainer Spanbroek,Jaime Llodra,Alexandre Garin,Jianhua Liu,Matthias Mack,Nico van Rooijen,Sergio A. Lira,Andreas J. R. Habenicht,Gwendalyn J. Randolph +12 more
TL;DR: Analyzing mouse monocyte subsets in apoE-deficient mice and tracing their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques suggests antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their C CR2-dependent responses to inflammation overall.
Journal ArticleDOI
Origin of the lamina propria dendritic cell network.
Milena Bogunovic,Florent Ginhoux,Julie Helft,Limin Shang,Daigo Hashimoto,Melanie Greter,Kang Liu,Claudia Jakubzick,Molly A. Ingersoll,Marylene Leboeuf,E. Richard Stanley,Michel C. Nussenzweig,Sergio A. Lira,Gwendalyn J. Randolph,Miriam Merad +14 more
TL;DR: It is shown that monocytes gave rise exclusively to CD103(-)CX(3)CR1(+) lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands.
Journal ArticleDOI
Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
Claudia Jakubzick,Claudia Jakubzick,Emmanuel L. Gautier,Sophie L. Gibbings,Dorothy K. Sojka,Andreas Schlitzer,Theodore E. Johnson,Stoyan Ivanov,Qiaonan Duan,Shashi Bala,Tracy Condon,Nico van Rooijen,John R. Grainger,Yasmine Belkaid,Avi Ma'ayan,David W. H. Riches,Wayne M. Yokoyama,Florent Ginhoux,Peter M. Henson,Gwendalyn J. Randolph,Gwendalyn J. Randolph +20 more
TL;DR: It is shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs) and can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophage by default.