D
Devanshi Patel
Researcher at Boston University
Publications - 9
Citations - 288
Devanshi Patel is an academic researcher from Boston University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 3, co-authored 8 publications receiving 171 citations.
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Journal ArticleDOI
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Joshua C. Bis,Xueqiu Jian,Brian W. Kunkle,Yuning Chen,Kara L. Hamilton-Nelson,William S. Bush,William J Salerno,Daniel Lancour,Yiyi Ma,Alan E. Renton,Edoardo Marcora,John J. Farrell,Yi Zhao,Liming Qu,Shahzad Ahmad,Najaf Amin,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Gary W. Beecham,Jennifer E. Below,Dominique Campion,Laura B. Cantwell,Camille Charbonnier,Jaeyoon Chung,Paul K. Crane,Carlos Cruchaga,L. Adrienne Cupples,Jean-François Dartigues,Stéphanie Debette,Jean-François Deleuze,Lucinda Fulton,Stacey Gabriel,Emmanuelle Génin,Richard A. Gibbs,Alison Goate,Benjamin Grenier-Boley,Namrata Gupta,Jonathan L. Haines,Aki S. Havulinna,Aki S. Havulinna,Seppo Helisalmi,Mikko Hiltunen,Daniel P. Howrigan,Daniel P. Howrigan,M. Arfan Ikram,Jaakko Kaprio,Jan Konrad,Amanda B. Kuzma,Eric S. Lander,Mark Lathrop,Terho Lehtimäki,Honghuang Lin,Kari Mattila,Richard Mayeux,Donna M. Muzny,Waleed Nasser,Benjamin M. Neale,Benjamin M. Neale,Kwangsik Nho,Gaël Nicolas,Devanshi Patel,Margaret A. Pericak-Vance,Markus Perola,Markus Perola,Markus Perola,Bruce M. Psaty,Olivier Quenez,Farid Rajabli,Richard Redon,Christiane Reitz,Anne M. Remes,Anne M. Remes,Veikko Salomaa,Chloé Sarnowski,Helena Schmidt,Michael A. Schmidt,Reinhold Schmidt,Hilkka Soininen,Timothy A. Thornton,Giuseppe Tosto,Christophe Tzourio,Sven J. van der Lee,Cornelia M. van Duijn,Otto Valladares,Badri N. Vardarajan,Li-San Wang,Weixin Wang,Ellen M. Wijsman,Richard K. Wilson,Daniela Witten,Kim C. Worley,Xiaoling Zhang,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Céline Bellenguez,Jean-Charles Lambert,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Mark J. Daly,Mark J. Daly,Mark J. Daly,Eric Boerwinkle,Eric Boerwinkle,Kathryn L. Lunetta,Anita L. DeStefano,Josée Dupuis,Eden R. Martin,Gerard D. Schellenberg,Sudha Seshadri,Sudha Seshadri,Adam C. Naj,Myriam Fornage,Lindsay A. Farrer +118 more
TL;DR: The Alzheimer’s Disease Sequencing Project undertook whole exome sequencing in 5,740 late-onset Alzheimer disease cases and 5,096 cognitively normal controls primarily of European ancestry, identifying novel and predicted functional genetic variants in genes previously associated with AD.
Journal ArticleDOI
Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
Devanshi Patel,Jesse Mez,Badri N. Vardarajan,Lyndsay A. Staley,Jaeyoon Chung,Xiaoling Zhang,John J. Farrell,Michael J. Rynkiewicz,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Craig C. Teerlink,Jeffery Stevens,Chris Corcoran,Josue D. Gonzalez Murcia,Oscar L. Lopez,Richard Mayeux,Jonathan L. Haines,Margaret A. Pericak-Vance,Gerard D. Schellenberg,John S. K. Kauwe,Kathryn L. Lunetta,Lindsay A. Farrer +22 more
TL;DR: Variants with high functional effect were observed in participants with Alzheimer disease but not in controls in NOTCH3, a gene previously associated with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and TREM2 that in homozygous form causes Nasu-Hakola disease.
Journal ArticleDOI
Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.
Devanshi Patel,Xiaoling Zhang,John J. Farrell,Jaeyoon Chung,Thor D. Stein,Kathryn L. Lunetta,Lindsay A. Farrer +6 more
TL;DR: In this paper, the authors investigated AD-related gene expression patterns in cell types in blood and brain and found additional evidence for the role of myeloid cells in AD risk.
Posted ContentDOI
Cell-type Specific Expression Quantitative Trait Loci Associated with Alzheimer Disease in Blood and Brain Tissue
Devanshi Patel,Xiaoling Zhang,John J. Farrell,Jaeyoon Chung,Thor D. Stein,Thor D. Stein,Kathryn L. Lunetta,Lindsay A. Farrer +7 more
TL;DR: This study identified cell-type specific expression patterns for established and potentially novel AD genes, found additional evidence for the role of myeloid cells in AD risk, and discovered potential novel blood and brain AD biomarkers that highlight the importance of cell- type specific analysis.
Journal ArticleDOI
Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants
TL;DR: In this paper, set-based methods to identify rare expression quantitative trait loci (eQTL) related to Alzheimer disease (AD) were investigated using gene expression data derived from blood donated by 713 Alzheimer's Disease Neuroimaging Initiative participants and from brain tissues donated by 475 Religious Orders Study/Memory and Aging Project participants.