Chris Corcoran

TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.

TL;DR: The genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for LOAD and thatPLD3 influences APP processing, and provides an example of how densely affected families may help to identify rare variants with large effects on risk for disease or other complex traits.

TL;DR: Atrial fibrillation, hypertension, and angina were associated with a greater rate of decline and may represent modifiable risk factors for secondary prevention in Alzheimer disease and the attenuated decline for diabetes and coronary artery bypass graft surgery may be due to selective survival.

TL;DR: Although one or more apolipoprotein E ε 4 alleles and ever use of FDA-approved antidementia medications were associated with initial MMSE scores, neither was related to the rate of progression in any domain.

TL;DR: The Cache County Study as discussed by the authors showed that women who used any type of HT within 5 years of menopause had 30% less risk of Alzheimer disease (95% confidence interval 0.49-0.99), especially if use was for 10 or more years.