D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
Mitochondria, Bioenergetics, and the Epigenome in Eukaryotic and Human Evolution
TL;DR: Common complex diseases may be the result of changes in any of a large number of mtDNA and nDNA bioenergetic genes or to altered epigenomic regulation of these bioener energetic genes.
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Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy.
Meagan J. McManus,Martin Picard,Martin Picard,Hsiao-Wen Chen,Hans J. De Haas,Prasanth Potluri,Jeremy Leipzig,Atif Towheed,Alessia Angelin,Partho P. Sengupta,Ryan M. Morrow,Brett A. Kauffman,Marc Vermulst,Jagat Narula,Douglas C. Wallace,Douglas C. Wallace +15 more
TL;DR: The strikingly different phenotypic effects of these mild mtDNA variants demonstrate that mtDNA can be an important modulator of autosomal disease and demonstrate that nuclear-encoded mutations can modulate the expressivity of nuclear DNA -encoded diseases.
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MITOMAP: an update on the status of the human mitochondrial genome database.
TL;DR: This paper is an update of the changes which have occurred to MITOMAP over the past year, which will provide a model for the development of comprehensive, multi-media information storage and retrieval systems for other components of the human genome.
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The epigenome and the mitochondrion: bioenergetics and the environment
TL;DR: Yoon et al. as mentioned in this paper conducted a siRNA knockdown survey of 6363 genes in mouse C2C12 cells and discovered 150 genes that regulated mitochondrial biogenesis and bioenergetics.
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Association Between Mitochondrial DNA Haplogroup Variation and Autism Spectrum Disorders.
Dimitra Chalkia,Larry N. Singh,Jeremy Leipzig,Maria Lvova,Olga Derbeneva,Anita Lakatos,Dexter Hadley,Hakon Hakonarson,Douglas C. Wallace,Douglas C. Wallace +9 more
TL;DR: Odds ratios of mitochondrial haplogroup as predictors of ASD risk show mtDNA haplogroups I, J, K, O-X, T, and U encompass 55% of the European population, and mtDNA lineages must make a significant contribution to overall ASD risk.