D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Mitochondrial cardiomyopathies: how to identify candidate pathogenic mutations by mitochondrial DNA sequencing, MITOMASTER and phylogeny
TL;DR: The automated information system, MITOMASTER, is used to make a preliminary distinction between normal mtDNA variation and pathogenic mutations in patient samples; this fast and easy approach allowed us to select the variants for traditional analysis to establish pathogenicity.
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Mitochondrial DNA variation in an aboriginal Australian population: evidence for genetic isolation and regional differentiation.
TL;DR: The mt-DNA data corroborate the genetic uniqueness of Aboriginal Australian populations and suggested that Aboriginal Australian and Papua New Guinea populations may have once shared an ancient ancestral population(s), and then rapidly diverged from each other once geographically separated.
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Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism
Supriya Shah,Whitney J. Carriveau,Jinyang Li,Sydney L. Campbell,Piotr K. Kopinski,Hee-Woong Lim,Natalie A. Daurio,Sophie Trefely,Kyoung-Jae Won,Douglas C. Wallace,Constantinos Koumenis,Anthony A. Mancuso,Kathryn E. Wellen +12 more
TL;DR: Evidence that metabolic features of prostate cancer cells can be exploited to sensitize CRPC cells to AR antagonism is provided, suggesting novel therapeutic opportunities for prostate cancer.
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Mitochondria and dystonia: The movement disorder connection?
TL;DR: In the current issue of these Proceedings, the association between the mitochondria and dystonia is extended by demonstrating that a mutation in a nuclear DNA gene encoding a protein involved in the import of mitochondrial inner membrane carrier proteins can also cause dySTONia.
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Adenine Nucleotide Translocase 1 Deficiency Results in Dilated Cardiomyopathy With Defects in Myocardial Mechanics, Histopathological Alterations, and Activation of Apoptosis
Nupoor Narula,Michael V. Zaragoza,Partho P. Sengupta,Peng Li,Neena B. Haider,Johan W. Verjans,Katrina G. Waymire,Mani A. Vannan,Douglas C. Wallace +8 more
TL;DR: It is demonstrated that mitochondrial energy deficiency is sufficient to cause dilated cardiomyopathy, confirming that energy defects are a factor in this disease.