D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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HDAC10 deletion promotes Foxp3+ T-regulatory cell function.
Satinder Dahiya,Ulf H. Beier,Liqing Wang,Rongxiang Han,Jing Jiao,Tatiana Akimova,Alessia Angelin,Douglas C. Wallace,Wayne W. Hancock +8 more
TL;DR: It is concluded that targeting of HDAC10 may be of therapeutic value for inflammatory disorders including colitis and also for transplantation.
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MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease
Lishuang Shen,Lishuang Shen,Maria Angela Diroma,Michael A. Gonzalez,Daniel Navarro-Gomez,Jeremy Leipzig,Marie T. Lott,Mannis van Oven,Douglas C. Wallace,Colleen Muraresku,Zarazuela Zolkipli-Cunningham,Patrick F. Chinnery,Marcella Attimonelli,Stephan Züchner,Marni J. Falk,Marni J. Falk,Xiaowu Gai,Xiaowu Gai +17 more
TL;DR: MSeqDR Disease Portal allows hierarchical tree‐style disease exploration to evaluate their unique descriptions, phenotypes, and causative variants and the development of a dynamic informed patient consent process to guide data access is underway to realize the full potential of these resources.
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Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis.
Scott L. Weiss,Donglan Zhang,Jenny Bush,Kathryn Graham,Jonathan Starr,Florin Tuluc,Sarah E. Henrickson,Todd J. Kilbaugh,Clifford S. Deutschman,Deborah G. Murdock,Francis X. McGowan,Lance B Becker,Douglas C. Wallace +12 more
TL;DR: Although initial mitochondrial alterations in peripheral blood mononuclear cells were unrelated to organ dysfunction, persistently low respiration was associated with slower recovery from organ dysfunction.
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Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function.
Eliana D. Weisz,Atif Towheed,Rachel E. Monyak,Meridith S Toth,Douglas C. Wallace,Douglas C. Wallace,Thomas A. Jongens +6 more
TL;DR: It is demonstrated that under supersaturating conditions, dfmr1 mutant mitochondria have significantly increased maximum electron transport system (ETS) capacity and electron micrographs of indirect flight muscle reveal striking morphological changes in the dfmR1 mutant mitochondrial mitochondria.
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The Peopling of Europe from the Maternal and Paternal Perspectives
TL;DR: The emerging similarities in the geographic patterns of autosomal, mtDNA, and Y-chromosome variation are striking, and congruence in the results of all three systems in relation to the demic expansion of the Neolithic Near Eastern farmers into Europe is begun.