D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
Up-regulation of Nuclear and Mitochondrial Genes in the Skeletal Muscle of Mice Lacking the Heart/Muscle Isoform of the Adenine Nucleotide Translocator
TL;DR: Results indicate that identification of genes up-regulated in the skeletal muscle of the Ant1-deficient mouse provides a novel method for identifying mammalian genes required for mitochondrial biogenesis.
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Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome.
Mariella Simon,Elodie Richard,Xinjian Wang,Mohsin Shahzad,Vincent Huang,Tanveer A. Qaiser,Prasanth Potluri,Sarah E. Mahl,Antonio Davila,Sabiha Nazli,Saege Hancock,Margret Yu,J. Jay Gargus,Richard Chang,Nada Al-Sheqaih,William G. Newman,Jose E. Abdenur,Arnold Starr,Rashmi S. Hegde,Thomas Dorn,Anke Busch,Eddie Park,Jie Wu,Hagen Schwenzer,Adrian Flierl,Catherine Florentz,Marie Sissler,Shaheen N. Khan,Ronghua Li,Min-Xin Guan,Thomas B. Friedman,Doris K. Wu,Vincent Procaccio,Sheikh Riazuddin,Douglas C. Wallace,Zubair M. Ahmed,Taosheng Huang,Saima Riazuddin +37 more
TL;DR: These findings establish lesions in NARS2 as a new cause for nonsyndromic hearing loss and Leigh syndrome and demonstrate decreased steady-state levels of mt-tRNAAsn in fibroblasts from the Leigh syndrome patients.
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Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes
TL;DR: The mouse Ant2 gene, like human ANT2, has an upstream GRBOX, yet this element is not associated with suppression of transcription, as hypothesized for human ANt2, indicating that additional studies will be required to fully understand the transcriptional regulation of both Ant1 and Ant2.
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Analysis of Mitochondrial DNA Diversity in the Aleuts of the Commander Islands and Its Implications for the Genetic History of Beringia
Olga Derbeneva,Rem I. Sukernik,N. V. Volodko,Seyed H. Hosseini,Marie T. Lott,Douglas C. Wallace +5 more
TL;DR: The phylogeny of haplogroup D complete sequences showed that the D2 root sequence type originated among the latest inhabitants of Beringia and the Aleut 8910A sublineage of D2 is a part of larger radiation of rooted D2, which gave rise to D2a (Na-Dene), D2b (Aleut), and D2c (Eskimo) sublineages.
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Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration.
M. Cristina Kenney,Marilyn Chwa,Shari R. Atilano,Janelle M. Pavlis,Payam Falatoonzadeh,Claudio Ramirez,Deepika Malik,Tiffany Hsu,Grace Woo,Kyaw Thu Soe,Anthony B. Nesburn,Anthony B. Nesburn,David S. Boyer,Baruch D. Kuppermann,S. Michal Jazwinski,Michael V. Miceli,Douglas C. Wallace,Nitin Udar +17 more
TL;DR: The findings demonstrate that mtDNA haplogroup variants mediate not only energy production and cell growth, but also cell signaling for major molecular pathways, including AMD, and support the hypothesis that mt DNA variants play important roles in numerous cellular functions and disease processes.