D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
William J. Quinn,Jing Jiao,Tara TeSlaa,Jason Stadanlick,Zhonglin Wang,Liqing Wang,Tatiana Akimova,Alessia Angelin,Patrick M. Schäfer,Michelle D. Cully,Caroline Perry,Piotr K. Kopinski,Lili Guo,Ian A. Blair,Louis R. Ghanem,Michael S. Leibowitz,Wayne W. Hancock,Edmund K. Moon,Matthew H. Levine,Evgeniy Eruslanov,Douglas C. Wallace,Joseph A. Baur,Ulf H. Beier +22 more
TL;DR: It is reported that nicotinamide adenine dinucleotide (NAD+), which is reduced to NADH by lactate dehydrogenase in lactate-rich conditions, is a key point of metabolic control in T cells and directly targeting the redox state may be a useful approach for developing novel immunotherapies in cancer and therapeutic immunosuppression.
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Transcriptional control of nuclear genes for the mitochondrial muscle ADP/ATP translocator and the ATP synthase beta subunit. Multiple factors interact with the OXBOX/REBOX promoter sequences.
TL;DR: The OXBOX/REBOX complex provides one mechanism by which mammalian energy metabolism can be adapted to developmental and environmental demands.
Journal ArticleDOI
Mitochondrial DNA in anucleate human blood cells.
TL;DR: Homogeneous populations of human blood platelets or erythrocytes were lysed in alkaline EDTA, bound to nitrocellulose and hybridized to a radioactive mtDNA probe and found that in nucleated cells, mitochondria contained multiple mtDNAs per mitochondrion.
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Elevated male European and female African contributions to the genomes of African American individuals.
Joanne M. Lind,Holli Hutcheson-Dilks,Scott M. Williams,Jason H. Moore,Myron Essex,Eduardo Ruiz-Pesini,Douglas C. Wallace,Sarah A. Tishkoff,Stephen J. O'Brien,Michael W. Smith +9 more
TL;DR: There is a threefold higher European male contribution compared with European females to the genomes of African American individuals meaning that admixture-based gene discovery will have the most power for the autosomes and will be more limited for X chromosome analysis.