D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
Expression of monoamine oxidase A and B activities in mouse cybrids and hybrids.
TL;DR: The inheritance of monoamine oxidase (MAO; EC1.3.4) was studied in cultured cells using techniques of somatic cell genetics to indicate that the genetic lesion in the neuroblastoma cells resulting in loss of MAO activity is not phenotypically dominant, and that both A and B types of activity can be conferred together to neuroblastomas cells which normally express only the A type ofMAO activity.
Journal ArticleDOI
DNA studies of limb-girdle muscular dystrophy type 2A in the Amish exclude a modifying mitochondrial gene and show no evidence for a modifying nuclear gene.
Book ChapterDOI
Aging and Degenerative Diseases
TL;DR: The hypothesis is that many of the age-related degenerative diseases of humans as well as aging itself are related to defects in the mitochondrial bioenergetic pathway: oxidative phosphorylation (OXPHOS).
Journal ArticleDOI
Sodium butyrate reverses lipopolysaccharide‐induced mitochondrial dysfunction in lymphoblasts
TL;DR: The hypothesis that butyrate could mitigate the decrease in mitochondrial respiration in immune cells under septic conditions is tested as a preliminary step towards better understanding the potential forbutyrate as a novel therapy in sepsis.
Journal ArticleDOI
An ultra-high bandwidth nano-electronic interface to the interior of living cells with integrated fluorescence readout of metabolic activity.
Dandan Ren,Zahra Nemati,Chia-Hung Lee,Jinfeng Li,Kamel Haddadi,Douglas C. Wallace,Peter Burke +6 more
TL;DR: An ultra-high bandwidth nano-electronic interface to the interior of living cells with integrated fluorescence readout of metabolic activity is presented, the first ever broadband, calibrated electrical connection to the inside of a cell.