D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Mourad Naïmi,Sylvie Bannwarth,Vincent Procaccio,Jean Pouget,Claude Desnuelle,Jean-François Pellissier,Agnès Rötig,Arnold Munnich,Patrick Calvas,Christian Richelme,Philippe Jonveaux,Giovanni Castelnovo,Mariella Simon,Michel Clanet,Douglas C. Wallace,Véronique Paquis-Flucklinger +15 more
TL;DR: This study illustrates the variability of phenotypes associated with mtDNA stability defects, increases the mutational spectrum of POLG variants and provides an efficient and reliable detection protocol for ANT1, TWINKLE and POLG mutational screening.
Mitochondrial DNA variation in Kets and Nganasans and the early peoples of Northern Eurasia
TL;DR: Specific features of the haplogroup geographical distribution along with the results of phylogenetic reconstruction favor the hypothesis of the genetic trace left in Eastern Cis-Urals and the adjacent Siberian territories by early migrations from the Near East.
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Mitotic segregation of cytoplasmic determinants for chloramphenicol resistance in mammalian cells II: Fusions with human cell lines.
TL;DR: The segregation of cytoplasmically inherited chloramphenicol resistance in mouse cells was investigated in fusions between CAP-resistant cells or cy toplasts (enucleated cells) and CAP-sensitive cells of varying tissue origin, indicating that CAP resistance is dominant.
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Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS
Valérie Desquiret-Dumas,Naïg Gueguen,Magalie Barth,Arnaud Chevrollier,Saege Hancock,Douglas C. Wallace,Patrizia Amati-Bonneau,Daniel Henrion,Dominique Bonneau,Pascal Reynier,Vincent Procaccio +10 more
TL;DR: In this paper, the m.3243A>G variant in the mitochondrial tRNA(Leu(UUR)) gene is a common mtDNA mutation and two strategies to compensate for the biochemical defects in the mutant cells: one consisted of lowering the glucose content in the culture medium, and the other involved the addition of larginine.
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Adenine Nucleotide Translocator 1 Deficiency Increases Resistance of Mouse Brain and Neurons to Excitotoxic Insults
TL;DR: Ant1-deficient mice are resistant to death induced by systemic exposure to the brain excitotoxin, kainic acid, and their hippocampal and cortical neurons are significantly more resistant to neuronal deathinduced by glutamate, KA, and etoposide.