D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
Papers
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Journal ArticleDOI
Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients
Michael D. Brown,John M. Shoffner,Yoon L. Kim,Albert S. Jun,Brett H. Graham,Margaret F. Cabell,Daniel S. Gurley,Douglas C. Wallace +7 more
TL;DR: The mitochondrial DNA sequence was determined on 3 patients with Alzheimer's disease exhibiting AD plus Parkinson's disease (PD) neuropathologic changes and one patient with PD, and 2 novel variants were observed among 25 base substitutions.
Journal ArticleDOI
Differences of sperm motility in mitochondrial DNA haplogroup U sublineages.
Francisco Montiel-Sosa,Eduardo Ruiz-Pesini,Eduardo Ruiz-Pesini,José Antonio Enríquez,Ana Marcuello,Carmen Díez-Sánchez,Julio Montoya,Douglas C. Wallace,Manuel J. López-Pérez +8 more
TL;DR: It is suggested that some of these ancient conserved cytb missense mutations permitted the authors' ancestors to adapt to cold by partially uncoupling mitochondrial oxidative phosphorylation (OXPHOS).
Book ChapterDOI
Animal models for mitochondrial disease.
TL;DR: These animal studies confirm that alterations in mitochondrial energy generation, ROS production, and apoptosis can all contribute to the pathophysiology of mitochondrial disease.
Journal ArticleDOI
mtDNA variation, climatic adaptation, degenerative diseases, and longevity.
Journal ArticleDOI
Association between mitochondrial DNA variations and Alzheimer's Disease in the ADNI cohort
Anita Lakatos,Olga Derbeneva,Danny Younes,David Keator,Trygve E. Bakken,Maria Lvova,Marty C. Brandon,Guia Guffanti,Dora Reglodi,Andrew J. Saykin,Michael W. Weiner,Fabio Macciardi,Nicholas J. Schork,Douglas C. Wallace,Steven G. Potkin +14 more
TL;DR: The results indicate that the mitochondrial haplogroup UK may confer genetic susceptibility to AD independently of the apolipoprotein E4 (APOE4) allele.