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Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Mouse lacking heart-muscle adenine nucleotide translocator protein and methods
TL;DR: In this article, transgenic mice genetically engineered for a deficiency of the heart-skeletal muscle isoform of the adenine nucleotide translocator protein (Ant1) were used for the first animal model for mitochondrial myopathy and hypertrophic cardiomyopathy.
Oxidative phosphorylation diseases and cerebellar ataxia.
John M. Shoffner,Allan Kaufman,Deborah A. Koontz,Nicolas Krawiecki,Erin N. Smith,Topp M,Douglas C. Wallace +6 more
TL;DR: This review focuses on the clinical, biochemical, and genetic features of OXPHOS diseases caused by mtDNA mutations in which ataxia is a common manifestation.
Journal ArticleDOI
Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts
Thomas J. Fielder,Charles S. Yi,Juliet Masumi,Katrina G. Waymire,Hsiao-Wen Chen,Shuling Wang,Kai-Xuan Shi,Douglas C. Wallace,Douglas C. Wallace,Grant R. MacGregor +9 more
TL;DR: Use of B6J host blastocysts for microinjection of ES cells may offer improvements over blastocyst from B6NTac and possibly other sub-strains of C57BL/6 mice.
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Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis : a distinct late onset mitochondrial disorder
Johan L. K. Van Hove,Sara Shanske,Federica Ciacci,Scott W. Ballinger,John Shoffner,Douglas C. Wallace,Takashi Hanioka,Karl Folkers,Edward H. Bossen,Peter S. Kussin,Jeffrey M. Kopita,Stephen G. Kahler +11 more
TL;DR: This patient represents a distinct clinical presentation of a mitochondrial disorder characterized by late onset mitochondrial myopathy, chronic anemia, cardiomyopathy, and lactic acidosis.
Journal ArticleDOI
Assignment of an oligomycin-resistance locus to human chromosome 10
TL;DR: The study assigns an ATPase oligomycin-resistance locus to human chromosome 10 and suggests that mouse and human subunits can combine in a functional enzyme complex.