D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
Mitochondrial DNA mutations in human degenerative diseases and aging
Douglas C. Wallace,John M. Shoffner,Ian A. Trounce,Michael D. Brown,Scott W. Ballinger,Marisol Corral-Debrinski,Terzah M. Horton,Albert S. Jun,Marie T. Lott +8 more
TL;DR: Novel features of mtDNA disease are proposed to be the product of the high dependence of the target organs on mitochondrial bioenergetics, and the cumulative oxidative phosphorylation (OXPHOS) defect caused by the inherited mtDNA mutation together with the age-related accumulation mtDNA mutations in post-mitotic tissues.
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The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
TL;DR: It is demonstrated that accelerating the mtDNA mutation rate can result in some features suggestive of premature aging, consistent with the view that loss of mitochondrial function is a major causal factor in aging.
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Mitochondrial DNA Variation in Koryaks and Itel'men: Population Replacement in the Okhotsk Sea-Bering Sea Region During the Neolithic
TL;DR: Results were consistent with colonization events associated with the relatively recent immigration to Kamchatka of new tribes from the Siberian mainland region, although remnants of ancient Beringian populations were still evident in the Koryak and Itel'men gene pools.
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The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J.
Michael D. Brown,Elena B. Starikovskaya,Olga Derbeneva,Seyed H. Hosseini,Jon C. Allen,Irina E. Mikhailovskaya,Rem I. Sukernik,Douglas C. Wallace +7 more
TL;DR: Results strongly support a role for haplogroup J in the expression of certain LHON mutations, including the homoplasmic 10663C mutation, which has been found in three independent LHON patients who lack a known primary mutation and all of which belong to haplogroups J.
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African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes.
Yuehai Ke,Bing Su,Bing Su,Bing Su,Xiufeng Song,Daru Lu,Lifeng Chen,Hongyu Li,Chunjian Qi,Sangkot Marzuki,Ranjan Deka,Peter A. Underhill,Chunjie Xiao,Mark D. Shriver,Jeff Lell,Douglas C. Wallace,R. Spencer Wells,Mark Seielstad,Peter J. Oefner,Dingliang Zhu,Jianzhong Jin,Wei Huang,Ranajit Chakraborty,Zhu Chen,Li Jin,Li Jin +25 more
TL;DR: The data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia and coalesce to another mutation which originated in Africa about 35,000 to 89,000 years ago.