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Douglas C. Wallace

Researcher at Children's Hospital of Philadelphia

Publications -  495
Citations -  77420

Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.

Papers
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Journal ArticleDOI

Wafer-scale mitochondrial membrane potential assays{

Tae-Sun Lim, +5 more
- 03 Jul 2012 - 
TL;DR: This second generation integrated lab-on-a-chip system developed here shows enhanced structural durability and reproducibility while increasing the sensitivity to changes in mitochondrial membrane potential by an order of magnitude as compared to first generation technologies.
Journal ArticleDOI

Genome-wide surveillance of transcription errors in response to genotoxic stress.

Clark Fritsch, +19 more
- 05 Jan 2021 - 
TL;DR: In this article, it was shown that in addition to genetic mutations, mutagens are also a powerful source of transcription errors, and DNA repair is required to mitigate transcriptional mutagenesis after exposure.
Journal ArticleDOI

Maternally Transmitted Diabetes and Deafness

Scott W. Ballinger, +1 more
- 01 Mar 1995 - 
Patent

Detection of mitochondrial DNA mutation 14459 associated with dystonia and/or Leber's hereditary optic neuropathy

Douglas C. Wallace, +1 more
TL;DR: In this article, an assay for diagnosing or predicting a predisposition to dystonia and/or Leber's hereditary optic neuropathy by detecting the presence of a mutation in mitochondrial DNA, in the OxPHOS gene ND6, that causes a substitution in amino acid 72 of the ND6 polypeptide.
Journal ArticleDOI

Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome

Mariella Simon, +37 more
- 01 Sep 2015 -