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Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Targeted down regulation of core mitochondrial genes during sars-cov-2 infection
Joseph W. Guarnieri,Joseph M. Dybas,Hossein Fazelinia,Man S. Kim,Justin J. Frere,Yuanchao Zhang,Yentli E. Soto Albrecht,Deborah G. Murdock,Alessia Angelin,Larry N. Singh,Scott T. Weiss,Sonja M. Best,Marie T. Lott,Henry D Cope,V. Zaksas,Amanda M. Saravia-Butler,Cem Meydan,Jonathan Foox,Christopher Mozsary,Yared H. Kidane,Waldemar Priebe,Mark R. Emmett,Robert Meller,Urminder Singh,Yaron Bram,Benjamin R. tenOever,Mark T. Heise,Nathaniel J. Moorman,Emily A Madden,Sharon Taft-Benz,Elizabeth J. Anderson,Wes Sanders,Rebekah J. Dickmander,Victoria K. Baxter,Stephen B. Baylin,Eve Syrkin Wurtele,Pedro M. Moraes-Vieira,Deanne Taylor,Christopher E. Mason,Jonathan C. Schisler,Robert E. Schwartz,Afshin Beheshti,Douglas C. Wallace +42 more
TL;DR: The dynamics of COVID-19 through transcription profiles in nasopharyngeal and autopsy samples from patients and infected rodent models are revealed and targeted enhancement of mitochondrial gene expression may mitigate the pathogenesis of CO VID-19.
Journal ArticleDOI
Mitochondrial DNA mutations associated with neuromuscular diseases: analysis and diagnosis using the polymerase chain reaction.
Douglas C. Wallace,Marie T. Lott,Angela M. S. Lezza,Peter Seibel,Peter Seibel,Alexander S. Voljavec,John M. Shoffner +6 more
TL;DR: Molecular analysis will likely become a primary tool for the diagnosis of neuromuscular diseases such as myoclonic epilepsy and ragged red fiber disease by identifying small deletions through amplification and electrophoretic analysis of the entire mtDNA genome.
Journal ArticleDOI
Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.
Jason E. Kokoszka,Katrina G. Waymire,Adrian Flierl,Katelyn Sweeney,Alessia Angelin,Grant R. MacGregor,Douglas C. Wallace +6 more
TL;DR: It is hypothesize that the developmental toxicity of the Ant2 null mutation may be the result of biasing the cardiomyocyte mtPTP to remain open thus impairing carduomyocyte maturation and resulting in cardiomeocyte hyperproliferation and failure of trabecular maturation.
Book ChapterDOI
PNA-Mediated PCR Clamping
Journal ArticleDOI
Selective killing of cells with oxidative defects in galactose medium: A screening test for affected patient fibroblasts
TL;DR: The cell lines showing susceptibility to galactose metabolism appear to be those with the more overt or severe oxidative defects, and the extent of the susceptibiity appears to bear some relationship to the nature of the oxidative defect.