D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal Article
Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation.
Edwin M. Stone,Nancy J. Newman,Neil R. Miller,Donald R. Johns,Marie T. Lott,Douglas C. Wallace +5 more
TL;DR: Five patients with Leber's hereditary optic neuropathy (LHON) and the 11778 mitochondrial mutation spontaneously recovered 20/40 or better visual acuity in at least one eye after months to years of legal blindness, indicating that a few individuals do recover near-normal vision even years after the initial visual loss.
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The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Atsushi Hoshino,Atsushi Hoshino,Wei-jia Wang,Wei-jia Wang,Shogo Wada,Chris McDermott-Roe,Chantell S. Evans,Bridget Gosis,Michael Morley,Komal S. Rathi,Komal S. Rathi,Jian Li,Kristina Li,Steven Yang,Meagan J. McManus,Caitlyn E. Bowman,Prasanth Potluri,Michael G. Levin,Scott M. Damrauer,Douglas C. Wallace,Erika L.F. Holzbaur,Zoltan Arany +21 more
TL;DR: It is shown that ANT is an essential and fundamental mediator of mitophagy in health and disease and that this role is independent of its nucleotide translocase activity.
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Mitochondria as Chi
TL;DR: The causes of these diseases remain a mystery, while their incidence and morbidity either remain constant or are increasing (Wallace 2005b) as discussed by the authors, while their causes remain unknown.
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Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populations
Rosaria Scozzari,Fulvio Cruciani,P Santolamazza,Patrizia Malaspina,Antonio Torroni,Antonio Torroni,Daniele Sellitto,B Arredi,Giovanni Destro-Bisol,G. F. De Stefano,Olga Rickards,Cristina Martínez-Labarga,David Modiano,Gianfranco Biondi,Pedro Moral,Antonel Olckers,Douglas C. Wallace,Andrea Novelletto +17 more
TL;DR: Despite some correspondence between language affiliation and genetic similarity, geographic proximity seems to be a better predictor of genetic affinity than language affiliation after populations were clustered into different configurations.
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Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes.
TL;DR: Examining three pairs of human diploid fibroblasts and their SV 40-transformed counterparts revealed that mRNAs for the nuclear-encoded ATP synthase beta and the adenine nucleotide translocator (ANT) isoform 1 and 2 genes were markedly induced, whereas the mRNA for the ANT isoform 3 gene remained unchanged.