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Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Multi-Organ Characterization of Mitochondrial Genomic Rearrangements in Ad Libitum and Caloric Restricted Mice Show Striking Somatic Mitochondrial DNA Rearrangements with Age
TL;DR: Observations confirm that mtDNA mutations accumulate with age in mice and suggest that caloric restriction impedes this progress, which is suggested to extend life span supporting an association between bioenergetics and senescence.
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Bioenergetic Origins of Complexity and Disease
TL;DR: This bioenergetic perspective on disease provides a unifying pathophysiological and genetic mechanism for neuropsychiatric diseases such as Alzheimer and Parkinson Disease, metabolic diseases, autoimmune diseases, aging, and cancer.
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MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences.
Marty C. Brandon,Eduardo Ruiz-Pesini,Dan Mishmar,Vincent Procaccio,Marie T. Lott,Kevin Cuong Nguyen,Syawal Spolim,Upen Patil,Pierre Baldi,Douglas C. Wallace +9 more
TL;DR: A computer system to make analysis of human mitochondrial DNA sequences efficient, accurate, and easily available and should be beneficial for mtDNA analyses of biomedical physicians and investigators, population biologists and forensic scientists.
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Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle
Martin Picard,Benoit J. Gentil,Meagan J. McManus,Kathryn White,Kyle St. Louis,Sarah E. Gartside,Douglas C. Wallace,Douglass M. Turnbull,Douglass M. Turnbull,Douglass M. Turnbull +9 more
TL;DR: The notion that mitochondrial membrane dynamics are actively remodelled in skeletal muscle, which may be regulated by contractile activity and the metabolic state, is supported.
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Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts.
TL;DR: New polymorphic variants in this family for the Hhal restriction endonuclease cleavage pattern of the mtDNA verifies the maternal inheritance of mtDNA through all three generations.