D
Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Book ChapterDOI
Oxidative phosphorylation diseases. Disorders of two genomes.
TL;DR: The mitochondrial cytopathies are a heterogeneous group of diseases associated with defects in mitochondrial ATP production that affect the brain, skeletal muscle, heart, kidney, and liver.
Journal ArticleDOI
The clinical characteristics of pedigrees of Leber's hereditary optic neuropathy with the 11778 mutation.
TL;DR: Genetic analysis showed the mitochondrial DNA mutation at position 11778, which established the diagnosis of Leber's hereditary optic neuropathy and has allowed for a broader view of the clinical features of this disease.
Journal ArticleDOI
The basal proton conductance of mitochondria depends on adenine nucleotide translocase content
Martin D. Brand,Julian L. Pakay,Augustine Ocloo,Jason E. Kokoszka,Douglas C. Wallace,Paul S. Brookes,Emma J. Cornwall +6 more
TL;DR: Half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions.
Journal ArticleDOI
A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes.
Fulvio Cruciani,P Santolamazza,Peidong Shen,Vincent Macaulay,Pedro Moral,Antonel Olckers,David Modiano,Susan Holmes,Giovanni Destro-Bisol,Valentina Coia,Valentina Coia,Douglas C. Wallace,Peter J. Oefner,Antonio Torroni,Luigi Luca Cavalli-Sforza,Rosaria Scozzari,Peter A. Underhill +16 more
TL;DR: Phylogeographic analyses suggest that a large component of the present Khoisan gene pool is eastern African in origin and that Asia was the source of a back migration to sub-Saharan Africa.
Journal Article
mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with native Americans
Antonio Torroni,Rem I. Sukernik,Theodore G. Schurr,Y B Starikorskaya,Margaret F. Cabell,Michael H. Crawford,A G Comuzzie,Douglas C. Wallace +7 more
TL;DR: The hypothesis that the first humans to move from Siberia to the Americas carried with them a limited number of founding mtDNAs is supported and that the initial migration occurred between 17,000-34,000 years before present.