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Douglas C. Wallace
Researcher at Children's Hospital of Philadelphia
Publications - 495
Citations - 77420
Douglas C. Wallace is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 134, co-authored 475 publications receiving 72035 citations. Previous affiliations of Douglas C. Wallace include University of California & Stanford University.
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Journal ArticleDOI
mtDNA Diversity in Chukchi and Siberian Eskimos: Implications for the Genetic History of Ancient Beringia and the Peopling of the New World
Yelena B. Starikovskaya,Rem I. Sukernik,Theodore G. Schurr,Andreas M. Kogelnik,Douglas C. Wallace +4 more
TL;DR: The sequence-divergence estimates for haplogroups A, C, and D of Siberian and Native American populations indicate that the earliest inhabitants of Beringia possessed a limited number of founding mtDNA haplotypes and that the first humans expanded into the New World approximately 34,000 years before present.
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Mitochondrial DNA mutations and neuromuscular disease
TL;DR: Point mutations have been associated with maternally inherited diseases, while deletions have been identified in some 'spontaneous' cases.
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Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations
TL;DR: Phylogenetic analysis of the nuclear CO1 and CO2 sequences revealed that they diverged from modern human mtDNAs early in hominid evolution about 770,000 years before present, consistent with the interpretation that the missense mutations proposed to cause AD may be the product of ancient mtDNA variants preserved as nuclear pseudogenes.
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Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder.
Brandi Rollins,Maureen V. Martin,P. Adolfo Sequeira,Emily A. Moon,Ling Morgan,Stanley J. Watson,Alan F. Schatzberg,Huda Akil,Richard M. Myers,Edward G. Jones,Douglas C. Wallace,William E. Bunney,Marquis P. Vawter +12 more
TL;DR: Focusing on haplogroup and individual susceptibility factors in psychiatric disorders by considering mtDNA variants may lead to innovative treatments to improve mitochondrial health and brain function.