D
Dylan Aïssi
Researcher at University of Paris
Publications - 14
Citations - 1167
Dylan Aïssi is an academic researcher from University of Paris. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 7, co-authored 10 publications receiving 991 citations. Previous affiliations of Dylan Aïssi include Institute of Chartered Accountants of Nigeria & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
DNA methylation and body-mass index: a genome-wide analysis
Katherine J. Dick,Katherine J. Dick,Christopher P. Nelson,Christopher P. Nelson,Loukia Tsaprouni,Johanna K. Sandling,Johanna K. Sandling,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Simone Wahl,Eshwar Meduri,Pierre-Emmanuel Morange,Harald Grallert,Melanie Waldenberger,Annette Peters,Jeanette Erdmann,Christian Hengstenberg,François Cambien,François Cambien,François Cambien,Alison H. Goodall,Alison H. Goodall,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Heribert Schunkert,John R. Thompson,Tim D. Spector,Christian Gieger,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Panos Deloukas,Panos Deloukas,Panos Deloukas,Nilesh J. Samani,Nilesh J. Samani +37 more
TL;DR: Increased BMI in adults of European origin is associated with increased methylation at the HIF3A locus in blood cells and in adipose tissue, and perturbation of hypoxia inducible transcription factor pathways could have an important role in the response to increased weight in people.
Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal ArticleDOI
Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
Mathieu Lemire,Syed H.E. Zaidi,Maria Ban,Bing Ge,Dylan Aïssi,Marine Germain,Irfahan Kassam,Mike Wang,Brent W. Zanke,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Philip S. Wells,Stephen Sawcer,Steven Gallinger,Tomi Pastinen,Thomas J. Hudson +15 more
TL;DR: Methylation levels at CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) in a panel of lymphocytes from 1,748 individuals, and long-range epigenetic networks uncovered by this approach may be relevant to normal and disease states.
Journal ArticleDOI
Robust validation of methylation levels association at CPT1A locus with lipid plasma levels
Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Alain Carrié,Alain Carrié,Alain Carrié,Pierre-Emmanuel Morange,Pierre-Emmanuel Morange,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët +10 more
TL;DR: Testing for associations the two CTP1A CpG sites found associated with lipid-related traits by Frazier-Wood et al. and plasma levels of both LDL and triglycerides (TG) in two independent studies had differences in sampling scheme, DNA methylation specimen, and array preprocessing approaches.
Journal ArticleDOI
Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH.
Vinh Truong,Siying Huang,Jessica Dennis,Mathieu Lemire,Nora Zwingerman,Dylan Aïssi,Dylan Aïssi,Irfahan Kassam,Claire Perret,Claire Perret,Philip S. Wells,Pierre-Emmanuel Morange,Michael D. Wilson,David-Alexandre Trégouët,David-Alexandre Trégouët +14 more
TL;DR: The role of epigenetic regulation of the PHGDH gene in triglyceride metabolism is highlighted, providing novel insights on putative intervention targets.