E
Eija Hamalainen
Researcher at University of Helsinki
Publications - 10
Citations - 1166
Eija Hamalainen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Population & Locus (genetics). The author has an hindex of 8, co-authored 10 publications receiving 959 citations. Previous affiliations of Eija Hamalainen include University of California, Los Angeles & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Padhraig Gormley,Verneri Anttila,Verneri Anttila,Bendik S. Winsvold,Bendik S. Winsvold,Priit Palta,Tõnu Esko,Tõnu Esko,Tõnu Esko,Tune H. Pers,Kai-How Farh,Kai-How Farh,Kai-How Farh,Ester Cuenca-León,Mikko Muona,Nicholas A. Furlotte,Tobias Kurth,Tobias Kurth,Andres Ingason,George McMahon,Lannie Ligthart,Gisela M. Terwindt,Mikko Kallela,Tobias Freilinger,Tobias Freilinger,Caroline Ran,Scott G. Gordon,Anine H. Stam,Stacy Steinberg,Guntram Borck,Markku Koiranen,Lydia Quaye,Hieab H.H. Adams,Terho Lehtimäki,Antti-Pekka Sarin,Juho Wedenoja,David A. Hinds,Julie E. Buring,Julie E. Buring,Markus Schürks,Paul M. Ridker,Paul M. Ridker,Maria Gudlaug Hrafnsdottir,Hreinn Stefansson,Susan M. Ring,Jouke-Jan Hottenga,Brenda W.J.H. Penninx,Markus Färkkilä,Ville Artto,Mari A. Kaunisto,Salli Vepsäläinen,Rainer Malik,Andrew C. Heath,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,Mitja I. Kurki,Mart Kals,Reedik Mägi,Kalle Pärn,Eija Hamalainen,Hailiang Huang,Hailiang Huang,Andrea Byrnes,Andrea Byrnes,Lude Franke,Jie Huang,Evie Stergiakouli,Phil Lee,Phil Lee,Cynthia Sandor,Caleb Webber,Zameel M. Cader,Zameel M. Cader,Bertram Müller-Myhsok,Stefan Schreiber,Thomas Meitinger,Johan G. Eriksson,Johan G. Eriksson,Veikko Salomaa,Kauko Heikkilä,Elizabeth Loehrer,Elizabeth Loehrer,André G. Uitterlinden,Albert Hofman,Cornelia M. van Duijn,Lynn Cherkas,Linda M. Pedersen,Audun Stubhaug,Audun Stubhaug,Christopher Sivert Nielsen,Christopher Sivert Nielsen,Minna Männikkö,Evelin Mihailov,Lili Milani,Hartmut Göbel,Ann-Louise Esserlind,Anne Francke Christensen,Thomas Hansen,Thomas Werge,Thomas Werge,Thomas Werge,Jaakko Kaprio,Jaakko Kaprio,Arpo Aromaa,Olli T. Raitakari,Olli T. Raitakari,M. Arfan Ikram,Tim D. Spector,Marjo-Riitta Järvelin,Andres Metspalu,Christian Kubisch,David P. Strachan,Michel D. Ferrari,Andrea Carmine Belin,Martin Dichgans,Maija Wessman,Arn M. J. M. van den Maagdenberg,John-Anker Zwart,John-Anker Zwart,Dorret I. Boomsma,George Davey Smith,Kari Stefansson,Kari Stefansson,Nicholas Eriksson,Mark J. Daly,Mark J. Daly,Benjamin M. Neale,Benjamin M. Neale,Jes Olesen,Daniel I. Chasman,Daniel I. Chasman,Dale R. Nyholt,Aarno Palotie +133 more
TL;DR: For example, the authors identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to date is the first to be identified on chromosome X.
Journal ArticleDOI
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Verneri Anttila,Bendik S. Winsvold,Bendik S. Winsvold,Padhraig Gormley,Tobias Kurth,Francesco Bettella,George McMahon,Mikko Kallela,Rainer Malik,Boukje de Vries,Gisela M. Terwindt,Sarah E. Medland,Unda Todt,Wendy L. McArdle,Lydia Quaye,Markku Koiranen,M. Arfan Ikram,Terho Lehtimäki,Anine H. Stam,Lannie Ligthart,Juho Wedenoja,Ian Dunham,Benjamin M. Neale,Benjamin M. Neale,Priit Palta,Priit Palta,Eija Hamalainen,Eija Hamalainen,Markus Schuerks,Lynda M. Rose,Julie E. Buring,Paul M. Ridker,Stacy Steinberg,Hreinn Stefansson,Finnbogi Jakobsson,Debbie A Lawlor,David M. Evans,Susan M. Ring,Markus Färkkilä,Ville Artto,Mari A. Kaunisto,Tobias Freilinger,Jean Schoenen,Rune R. Frants,Nadine Pelzer,Claudia M Weller,Ronald Zielman,Andrew C. Heath,Pamela A. F. Madden,Grant W. Montgomery,Nicholas G. Martin,Guntram Borck,Hartmut Goebel,Axel Heinze,Katja Heinze-Kuhn,Frances M K Williams,Anna-Liisa Hartikainen,Anneli Pouta,Joyce van den Ende,André G. Uitterlinden,Albert Hofman,Najaf Amin,Jouke-Jan Hottenga,Jacqueline M. Vink,Kauko Heikkilä,Michael Alexander,Bertram Müller-Myhsok,Stefan Schreiber,Thomas Meitinger,Heinz Erich Wichmann,Arpo Aromaa,Johan G. Eriksson,Bryan J. Traynor,Daniah Trabzuni,Elizabeth J. Rossin,Elizabeth J. Rossin,Kasper Lage,Suzanne B.R. Jacobs,J. Raphael Gibbs,J. Raphael Gibbs,Ewan Birney,Jaakko Kaprio,Jaakko Kaprio,Brenda W. J. H. Penninx,Dorret I. Boomsma,Cornelia M. van Duijn,Olli T. Raitakari,Marjo-Riitta Järvelin,John-Anker Zwart,Lynn Cherkas,David P. Strachan,Christian Kubisch,Michel D. Ferrari,Arn M. J. M. van den Maagdenberg,Martin Dichgans,Maija Wessman,George Davey Smith,Kari Stefansson,Kari Stefansson,Mark J. Daly,Mark J. Daly,Dale R. Nyholt,Daniel I. Chasman,Daniel I. Chasman,Aarno Palotie,Aarno Palotie,Aarno Palotie +106 more
TL;DR: A meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls, identified 12 loci associated with migraine susceptibility.
Journal ArticleDOI
A Susceptibility Locus for Migraine with Aura, on Chromosome 4q24
Maija Wessman,Mikko Kallela,Mari A. Kaunisto,Pia Marttila,Eric M. Sobel,Jaana Hartiala,Greg Oswell,Suzanne M. Leal,Jeanette C. Papp,Eija Hamalainen,Eija Hamalainen,Petra Broas,Geoffrey Joslyn,Iiris Hovatta,Tero Hiekkalinna,Jaakko Kaprio,Jaakko Kaprio,Jurg Ott,Rita M. Cantor,John-Anker Zwart,John-Anker Zwart,Matti Ilmavirta,Hannele Havanka,Markus Färkkilä,Leena Peltonen,Aarno Palotie,Aarno Palotie +26 more
TL;DR: Results from a genomewide screen of 50 multigenerational, clinically well-defined Finnish families showing intergenerational transmission of migraine with aura (MA) show significant evidence of linkage between the MA phenotype and marker D4S1647 on 4q24.
Posted ContentDOI
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Padhraig Gormley,Verneri Anttila,Bendik S. Winsvold,Priit Palta,Tõnu Esko,Tune H. Pers,Kai-How Farh,Ester Cuenca-León,Mikko Muona,Nicholas A. Furlotte,Tobias Kurth,Andres Ingason,George McMahon,Lannie Ligthart,Gisela M. Terwindt,Mikko Kallela,Tobias Freilinger,Caroline Ran,Scott G. Gordon,Anine H. Stam,Stacy Steinberg,Guntram Borck,Markku Koiranen,Lydia Quaye,Hieab H.H. Adams,Terho Lehtimäki,Antti-Pekka Sarin,Juho Wedenoja,David A. Hinds,Julie E. Buring,Markus Schürks,Paul M. Ridker,Maria Gudlaug Hrafnsdottir,Hreinn Stefansson,Susan M. Ring,Jouke-Jan Hottenga,Brenda W.J.H. Penninx,Markus Färkkilä,Ville Artto,Mari A. Kaunisto,Salli Vepsäläinen,Rainer Malik,Andrew C. Heath,Pamela A. F. Madden,Nicholas G. Martin,Grant W. Montgomery,Eija Hamalainen,Hailiang Huang,Andrea Byrnes,Lude Franke,Jie Huang,Evie Stergiakouli,Phil Lee,Cynthia Sandor,Caleb Webber,Zameel M. Cader,Bertram Müller-Myhsok,Stefan Schreiber,Thomas Meitinger,Johan G. Eriksson,Veikko Salomaa,Kauko Heikkilä,Elizabeth Loehrer,André G. Uitterlinden,Albert Hofman,Cornelia M. van Duijn,Lynn Cherkas,Linda M. Pedersen,Audun Stubhaug,Christopher Sivert Nielsen,Minna Männikkö,Evelin Mihailov,Lili Milani,Hartmut Göbel,Ann-Louise Esserlind,Anne Francke Christensen,Thomas Hansen,Thomas Werge,Jaakko Kaprio,Arpo Aromaa,Olli T. Raitakari,M. Arfan Ikram,Tim D. Spector,Marjo-Riitta Järvelin,Andres Metspalu,Christian Kubisch,David P. Strachan,Michel D. Ferrari,Andrea Carmine Belin,Martin Dichgans,Maija Wessman,Arn M. J. M. van den Maagdenberg,John-Anker Zwart,Dorret I. Boomsma,George Davey Smith,Kari Stefansson,Nicholas Eriksson,Mark J. Daly,Benjamin M. Neale,Jes Olesen,Daniel I. Chasman,Dale R. Nyholt,Aarno Palotie +102 more
TL;DR: The largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies, identified 45 independent single nucleotide polymorphisms significantly associated with migraine risk that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X.
Journal ArticleDOI
Consistently Replicating Locus Linked to Migraine on 10q22-q23
Verneri Anttila,Dale R. Nyholt,Mikko Kallela,Ville Artto,S. Vepsalainen,Eveliina Jakkula,Annika Wennerström,P. Tikka-Kleemola,Mari A. Kaunisto,Eija Hamalainen,Elisabeth Widen,Joseph D. Terwilliger,Joseph D. Terwilliger,Kathleen R. Merikangas,Grant W. Montgomery,Nicholas G. Martin,Mark J. Daly,Jaakko Kaprio,Leena Peltonen,Markus Färkkilä,Maija Wessman,Aarno Palotie +21 more
TL;DR: The results of two genome-wide scans in two diverse populations in which a consistent use of recently introduced migraine-phenotyping methods detects and replicates a locus on 10q22-q23, with an additional independent replication was presented in this paper.