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Elke Holinski-Feder
Researcher at Ludwig Maximilian University of Munich
Publications - 5
Citations - 643
Elke Holinski-Feder is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 5, co-authored 5 publications receiving 581 citations.
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Journal ArticleDOI
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database
Bryony A. Thompson,Bryony A. Thompson,Amanda B. Spurdle,John-Paul Plazzer,Marc S. Greenblatt,Kiwamu Akagi,Fahd Al-Mulla,Bharati Bapat,Inge Bernstein,Gabriel Capellá,Johan T. den Dunnen,Desirée du Sart,Aurelie Fabre,Michael Farrell,Susan M. Farrington,Ian M. Frayling,Thierry Frebourg,David E. Goldgar,David E. Goldgar,Christopher D. Heinen,Elke Holinski-Feder,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Kristina Lagerstedt Robinson,Suet Yi Leung,Alexandra Martins,Pål Møller,Monika Morak,Minna Nyström,Päivi Peltomäki,Marta Pineda,Ming Qi,Ming Qi,Rajkumar Ramesar,Lene Juel Rasmussen,Brigitte Royer-Pokora,Rodney J. Scott,Rodney J. Scott,Rolf H. Sijmons,Sean V. Tavtigian,Carli M. J. Tops,Thomas P. Weber,Juul T. Wijnen,Michael O. Woods,Finlay A. Macrae,Maurizio Genuardi +46 more
TL;DR: This large-scale endeavor will facilitate the consistent management of families suspected to have Lynch syndrome and demonstrates the value of multidisciplinary collaboration in the curation and classification of variants in public locus-specific databases.
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Association between TAS2R38 gene polymorphisms and colorectal cancer risk: A case-control study in two independent populations of caucasian origin
Maura Carrai,Verena Steinke,Pavel Vodicka,Pavel Vodicka,Barbara Pardini,Nils Rahner,Elke Holinski-Feder,Monika Morak,Hans K. Schackert,Heike Görgens,Susanne Stemmler,Beate Betz,Matthias Kloor,Christoph Engel,Reinhard Büttner,Alessio Naccarati,Ludmila Vodickova,Ludmila Vodickova,Jan Novotny,Angelika Stein,Kari Hemminki,Kari Hemminki,Peter Propping,Asta Försti,Asta Försti,Federico Canzian,Roberto Barale,Daniele Campa,Daniele Campa +28 more
TL;DR: A suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin is found.
Journal ArticleDOI
Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
Jesús Lascorz,Asta Försti,Asta Försti,Bowang Chen,Stephan Buch,Verena Steinke,Nils Rahner,Elke Holinski-Feder,Monika Morak,Hans K. Schackert,Heike Görgens,Karsten Schulmann,Timm O. Goecke,Matthias Kloor,Cristoph Engel,Reinhard Büttner,Nelli Kunkel,Marianne Weires,Michael Hoffmeister,Barbara Pardini,Alessio Naccarati,Ludmila Vodickova,Jan Novotny,Stefan Schreiber,Michael Krawczak,Clemens Dieter Bröring,Henry Völzke,Clemens Schafmayer,Pavel Vodicka,Jenny Chang-Claude,Hermann Brenner,Barbara Burwinkel,Peter Propping,Jochen Hampe,Kari Hemminki +34 more
TL;DR: The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events, and three software tools successfully pointed to the overrepresentation of genes related to the mitogen-activated protein kinase (MAPK) signalling pathways among the 1340 most strongly associated markers from the GWAS.
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Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3
Rongxi Yang,Rongxi Yang,Bowang Chen,Katrin Pfütze,Katrin Pfütze,Stephan Buch,Verena Steinke,Elke Holinski-Feder,Sarah Stöcker,Witigo von Schönfels,Thomas Becker,Hans K. Schackert,Brigitte Royer-Pokora,Matthias Kloor,Wolff Schmiegel,Reinhard Büttner,Christoph Engel,Jesus Lascorz Puertolas,Asta Försti,Asta Försti,Nelli Kunkel,Peter Bugert,Stefan Schreiber,Michael Krawczak,Clemens Schafmayer,Peter Propping,Jochen Hampe,Kari Hemminki,Barbara Burwinkel +28 more
TL;DR: Wang et al. as mentioned in this paper performed a genome-wide investigation of copy number variations (CNVs) on genomic DNA from 384 familial CRC cases and 1285 healthy controls by the Affymetrix 6.0 array and found an increase of overall CNV burden in familial CRC patients compared with healthy controls, especially for CNVs larger than 50kb.
Journal ArticleDOI
Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
Daniele Campa,Daniele Campa,Barbara Pardini,Alessio Naccarati,Ludmila Vodickova,Jan Novotny,Verena Steinke,Nils Rahner,Elke Holinski-Feder,Monika Morak,Hans K. Schackert,Heike Görgens,Judith Kötting,Beate Betz,Matthias Kloor,Christoph Engel,Reinhard Büttner,Peter Propping,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Roberto Barale,Pavel Vodicka,Federico Canzian +24 more
TL;DR: A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect, and two SNPs associated with lower risk of colorectal cancer, namely SNPsrs27647 and rs35683 were found.