다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

PREAMBLE......e4

APPENDIX 1......e121

APPENDIX 2......e122

APPENDIX 3......e124

REFERENCES......e124

It is important that the medical profession play a significant role in critically evaluating the use of diagnostic procedures and therapies as they are introduced in the detection, management,

/pdf/acc-aha-2006-guidelines-for-the-management-of-patients-with-27qfh9fc7i.pdf

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

Interleukin-10 and the interleukin-10 receptor.

Prospective Cohort Study

Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma

IgA deficiency is the most common humoral immune defect. We examined blood lymphocytes from 4 patients with Ataxia Telangiectasia and 6 with common IgA deficiency. All had absent serum IgA but .5–2% sIgA+ circulating B cells. PWM and EBV were used for the stimulation of these cells either in high density cultures (106 cells/well) or in low density, limiting dilution cultures (1–104 cells/well), which restrict cell:cell interactions. IgG, A and M secreted into culture supernates was measured by RIA and ELISA after 8 d (PWM) or 4 wk of culture (EBV). Cells from patients failed to produce IgA in high density cultures. In EBV stimulated limiting dilution cultures, IgA producing cells were detected in all patients. The frequency of IgA-committed, EBV transformable cells was normal in patients with uncomplicated IgA deficiency (approximately 1/100 B cells). However, in patients with AT, the frequency of IgA producing cells was up to 40 times lower. Our experiments demonstrate the presence of IgA producing cells in all patients with IgA deficiency studied. No evidence for IgA specific B cell defects could be delineated in common IgA deficiency. In AT, abnormalities of B cell differentiation may lead to the development of a smaller, IgA-committed B cell compartment. Supported by the Arthritis Society, MRC and NCI of Canada.

/pdf/1028-functional-analysis-of-iga-producing-cells-from-36emr8mi5w.pdf

1028 FUNCTIONAL ANALYSIS OF IgA PRODUCING CELLS FROM PATIENTS WITH SELECTIVE IgA DEFICIENCY

Inhibition of Pim1 Kinase Attenuates Respiratory Syncytial Virus (RSV) Re-Infection-Induced Enhanced Airway Hyperresponsiveness (AHR) and Inflammation

Ouabain inhibits the progression phase of mitogen induced t cell proliferation

Effects of Environmental Tobacco Smoke and Ambient PM2.5 Exposure on Albuterol Usage in Denver Schoolchildren.

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a variety of phenotypic changes on normal and malignant cells. In chronic and acute lymphocytic leukemia we have observed a marked augmentation in mixed lymphocyte reaction stimulatory capacity (MLRs) following pretreatment of leukemia blasts with TPA. We have now characterized the effects of TPA on MLRs utilizing the non-T, non-B lymphoblastic leukemiacell line, HOON. Following pretreatment with TPA (optimal concentration, 1.6×10−10M), but not with other phorbol esters, there was a marked increase in MLRs, particularly at lower stimulator-cell concentrations. This effect was maximal following a 44-hr preincubation period and the enhancement in MLRs was not accompanied by changes in levels of Ia expression. This cell line provides a model for determining the molecular basis for the TPA-induced augmentation of stimulatory capacity in the mixed lymphocyte reaction.

Erwin W. Gelfand

Papers

1028 FUNCTIONAL ANALYSIS OF IgA PRODUCING CELLS FROM PATIENTS WITH SELECTIVE IgA DEFICIENCY

Inhibition of Pim1 Kinase Attenuates Respiratory Syncytial Virus (RSV) Re-Infection-Induced Enhanced Airway Hyperresponsiveness (AHR) and Inflammation

Ouabain inhibits the progression phase of mitogen induced t cell proliferation

Effects of Environmental Tobacco Smoke and Ambient PM2.5 Exposure on Albuterol Usage in Denver Schoolchildren.

Augmentation of mixed lymphocyte response. Stimulatory activity by phorbol ester.