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Erwin W. Gelfand
Researcher at University of Colorado Denver
Publications - 679
Citations - 37565
Erwin W. Gelfand is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Immunoglobulin E & T cell. The author has an hindex of 99, co-authored 675 publications receiving 36059 citations. Previous affiliations of Erwin W. Gelfand include University of Colorado Hospital & University of Virginia.
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Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization.
Jürgen Schwarze,Grzegorz Cieslewicz,Anthony Joetham,Toshihide Ikemura,Mika J. Mäkelä,Azzeddine Dakhama,Leonard D. Shultz,Marinus C. Lamers,Erwin W. Gelfand +8 more
TL;DR: It is concluded that both IL-5, particularly during acute infection, and IL-4 are critical in mediating the effects of RSV infection on allergic airway sensitization, resulting in the development of AHR and lung eosinophilia.
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IFN-γ Production during Initial Infection Determines the Outcome of Reinfection with Respiratory Syncytial Virus
Young Mok Lee,Nobuaki Miyahara,Katsuyuki Takeda,John Prpich,Anita Oh,Annette Balhorn,Anthony Joetham,Erwin W. Gelfand,Azzeddine Dakhama +8 more
TL;DR: Provision of IFN-γ during primary infection in infancy may be a potential therapeutic approach to alter the course of RSV-mediated long-term sequelae and protection against AHR and lung histopathology on reinfection.
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Reduction of antigen-induced airway hyperreactivity and eosinophilia in ICAM-1-deficient mice.
Walter W. Wolyniec,G. T. De Sanctis,G. Nabozny,C. Torcellini,N. Haynes,Anthony Joetham,Erwin W. Gelfand,Jeffrey M. Drazen,Thomas Noonan +8 more
TL;DR: It is concluded that ICAM-1 is an important ligand mediating T-cell proliferation in response to antigen, eosinophil migration into the airways, and the development of airway hyperreactivity (AHR) in allergen-sensitized and -challenged mice.
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Mast cell-derived tumour necrosis factor is essential for allergic airway disease.
Sebastian Reuter,Andreas Heinz,M. Sieren,Rainer Wiewrodt,Erwin W. Gelfand,Michael Stassen,Roland Buhl,Christian Taube +7 more
TL;DR: The present results demonstrate the significance of mast cells in the development of airway disease and highlight the importance of mast cell-derived tumour necrosis factor in these responses.
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Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations.
Charline Miot,Kohsuke Imai,Chihaya Imai,Anthony J. Mancini,Anthony J. Mancini,Zeynep Yesim Kucuk,Tokomki Kawai,Ryuta Nishikomori,Etsuro Ito,Isabelle Pellier,Sophie Dupuis Girod,Jérémie Rosain,Shinya Sasaki,Shanmuganathan Chandrakasan,Shanmuganathan Chandrakasan,Jana Pachlopnik Schmid,Tsubasa Okano,Estelle Colin,Alberto Olaya-Vargas,Marco Antonio Yamazaki-Nakashimada,Waseem Qasim,Sara Espinosa Padilla,Andrea M. Jones,Alfons Krol,Nyree Cole,Stephen Jolles,Jack J. Bleesing,Thomas Vraetz,Andrew R. Gennery,Mario Abinun,Mario Abinun,Tayfun Güngör,Beatriz Tavares Costa-Carvalho,Antonio Condino-Neto,Paul Veys,Steven M. Holland,Gulbu Uzel,Despina Moshous,Benedicte Neven,Stéphane Blanche,Stephan Ehl,Rainer Doffinger,Smita Y. Patel,Anne Puel,Anne Puel,Anne Puel,Jacinta Bustamante,Erwin W. Gelfand,Jean-Laurent Casanova,Jordan S. Orange,Capucine Picard +50 more
TL;DR: Overall, HSCT can cure most clinical features of patients with a variety of IKBKG mutations, and the underlying mutation does not appear to have any influence, as patients with the same mutation had different outcomes.