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Erwin W. Gelfand
Researcher at University of Colorado Denver
Publications - 679
Citations - 37565
Erwin W. Gelfand is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Immunoglobulin E & T cell. The author has an hindex of 99, co-authored 675 publications receiving 36059 citations. Previous affiliations of Erwin W. Gelfand include University of Colorado Hospital & University of Virginia.
Papers
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Journal ArticleDOI
Systemic and local interferon gamma gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice.
TL;DR: Either systemic or local pulmonary delivery of a Th1 cytokine gene such as IFN-gamma may be an effective approach for treatment of allergen-induced asthma.
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Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation
Shigeki Matsubara,Toshiyuki Koya,Katsuyuki Takeda,Anthony Joetham,Nobuaki Miyahara,Polly Pine,Esteban Masuda,Christina H. Swasey,Erwin W. Gelfand +8 more
TL;DR: It is demonstrated that Syk inhibition prevents allergen-induced AHR and airway inflammation after systemic sensitization and challenge, at least in part through alteration of DC function.
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Volume regulation by human lymphocytes: characterization of the ionic basis for regulatory volume decrease.
TL;DR: The mechanism of volume regulation in hypotonic media was analysed in human peripheral blood mononuclear (PBM) cells and suggest that RVD occurs largely by a passive loss of cellular K+, resulting from a selective increase in permeability to this ion.
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Quantitative computed tomography detects peripheral airway disease in asthmatic children
TL;DR: Air‐trapping as quantified by high‐resolution computed tomography (HRCT) of the chest with measures of lung function and airway inflammation in children with mild to moderate asthma suggest that quantitative HRCT may be a useful tool in the evaluation of peripheral airflow obstruction inChildren with asthma.
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Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.
Masakazu Okamoto,Hiroyuki Matsuda,Anthony Joetham,Joseph J. Lucas,Joanne Domenico,Koji Yasutomo,Katsuyuki Takeda,Erwin W. Gelfand +7 more
TL;DR: The essential role of the interactions between Notch on CD4+ T cells and Jagged1 on APCs in the initiation of IL-4 production and Th2 differentiation for the development of AHR and allergic airway inflammation is identified.