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Erwin W. Gelfand
Researcher at University of Colorado Denver
Publications - 679
Citations - 37565
Erwin W. Gelfand is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Immunoglobulin E & T cell. The author has an hindex of 99, co-authored 675 publications receiving 36059 citations. Previous affiliations of Erwin W. Gelfand include University of Colorado Hospital & University of Virginia.
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Journal ArticleDOI
Regulation of immunoglobulin production by nerve growth factor: comparison with anti-CD40.
Chaya Brodie,Erwin W. Gelfand +1 more
TL;DR: Although NGFR and CD40 are expressed in a co-ordinate fashion on B cells and exert similar effects on Ig secretion, differences in interaction with other growth factors may be important in their activities at different stages of B-cell differentiation.
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Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen
Jung Won Park,Christian Taube,Eun Seok Yang,Anthony Joetham,Annette Balhorn,Katsuyuki Takeda,Nobuaki Miyahara,Azzeddine Dakhama,Debra D. Donaldson,Erwin W. Gelfand +9 more
TL;DR: The results indicate that despite some similarities, the mechanisms leading to AHR induced by RSV are different from those that follow allergen sensitization and challenge, and IL-13i could play an important role in preventing the consequences of viral infection in patients with allergic asthma.
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IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
Bryn H. Salt,Julie E. Niemela,Rahul Pandey,Eric P. Hanson,Raquel P. Deering,Ralph Quinones,Ashish Jain,Jordan S. Orange,Erwin W. Gelfand +8 more
TL;DR: A novel NEMO missense mutation is demonstrated that highlights a dispensability of the region including amino acid 113 for TLR signaling and ectodysplasin A receptor function, required for certain immunoreceptor functions as demonstrated by a 6-month-old boy's susceptibility to infections as well as natural killer cell and T-cell defects.
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Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency.
Rochelle Hirschhorn,Howard Ratech,Arye Rubinstein,Photini S Papageorgiou,Hernant Kesarwala,Erwin W. Gelfand,Vivien Roegner-Maniscalco +6 more
TL;DR: Accumulation in ADA deficient patients of two newly detected modified adenine nucleosides or their metabolites could play a role in explaining the profound abnormalities of B cell function seen in ADA deficiency but not in purineucleoside phosphorylase deficiency.
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Humoral immunity in steroid-dependent children with asthma and hypogammaglobulinemia
TL;DR: Patients with asthma, and with hypogammaglobulinemia resulting from steroid therapy, have normal humoral immunity, and immunoglobulin replacement therapy is not indicated.