E
Erwin W. Gelfand
Researcher at University of Colorado Denver
Publications - 679
Citations - 37565
Erwin W. Gelfand is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Immunoglobulin E & T cell. The author has an hindex of 99, co-authored 675 publications receiving 36059 citations. Previous affiliations of Erwin W. Gelfand include University of Colorado Hospital & University of Virginia.
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Loss of T Regulatory Cell Suppression following Signaling through Glucocorticoid-induced Tumor Necrosis Receptor (GITR) Is Dependent on c-Jun N-terminal Kinase Activation
Anthony Joetham,Hiroshi Ohnishi,Masakazu Okamoto,Katsuyuki Takeda,Michaela Schedel,Joanne Domenico,Azzeddine Dakhama,Erwin W. Gelfand +7 more
TL;DR: Treatment with an inhibitor of JNK phosphorylation resulted in complete reversal of all GITR-induced changes in nTreg phenotype and function, with full restoration of suppression of in vivo lung allergic responses and in vitro proliferation of activated CD4+CD25− T cells.
Journal Article
Platelet-activating factor enhances Ig production in B lymphoblastoid cell lines.
TL;DR: Data indicate that PAF may have an important immunomodulatory role in the production of Ig by B lymphocytes, and an ELISA spot assay for enumeration of Ig-secreting cells demonstrated that the increase in Ig production is likely due to enhancement of single cell Ig secretion rather than an increase in cell number.
Journal Article
Functional differentiation of B lymphocytes in congenital agammaglobulinemia. I. Generation of hemolytic plaque-forming cells.
TL;DR: Findings indicate the presence of B lymphocyte precursors in the majority of patients with cAgamma investigated, and specifically a specific hemolytic plaque-forming cell response in vitro to sheep red blood cells and ovalbumin.
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Disseminated Legionella pneumophila infection in an infant with severe combined immunodeficiency
TL;DR: A case of fatal Legionnaire disease is reported in an infant with severe combined immunodeficiency who developed disseminated infection involving the lungs, liver, and brain.
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Calcium-induced ERK activation in human T lymphocytes
TL;DR: The activation of ERK1 and 2 by calcium ionophores was rapid, transient, and occurred in a dose-dependent manner in human primary and Jurkat T lymphocytes as mentioned in this paper.