H
Hans-Peter Lenhof
Researcher at Saarland University
Publications - 170
Citations - 6982
Hans-Peter Lenhof is an academic researcher from Saarland University. The author has contributed to research in topics: Cancer & Macromolecular docking. The author has an hindex of 44, co-authored 164 publications receiving 6046 citations. Previous affiliations of Hans-Peter Lenhof include Max Planck Society.
Papers
More filters
Journal ArticleDOI
GeneTrail—advanced gene set enrichment analysis
Christina Backes,Andreas Keller,Jan Kuentzer,Benny Kneissl,Nicole Comtesse,Yasser A. Elnakady,Rolf Müller,Eckart Meese,Hans-Peter Lenhof +8 more
TL;DR: GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably and is freely accessible at http://genetrail.uni-sb.de.
Journal ArticleDOI
Toward the blood-borne miRNome of human diseases
Andreas Keller,Petra Leidinger,Andrea S. Bauer,Abdou ElSharawy,Jan Haas,Christina Backes,Anke Wendschlag,Nathalia Giese,Christine Tjaden,Katja Ott,Jens Werner,Thilo Hackert,Klemens Ruprecht,Hanno Huwer,Junko Huebers,Gunnar Jacobs,Philip Rosenstiel,Henrik Dommisch,Arne S. Schaefer,Joachim Müller-Quernheim,Bernd Wullich,Bastian Keck,Norbert Graf,Joerg Reichrath,Britta Vogel,Almut Nebel,Sven Uwe Jager,Peer F Staehler,Ioannis Amarantos,Valesca Boisguerin,Cord F Staehler,Markus Beier,Matthias Scheffler,Markus W. Büchler,J Wischhusen,Sebastian F M Haeusler,Johannes Dietl,Sylvia Hofmann,Hans-Peter Lenhof,Stefan Schreiber,Hugo A. Katus,Wolfgang Rottbauer,Benjamin Meder,Joerg Hoheisel,Andre Franke,Eckart Meese +45 more
TL;DR: In a multicenter study, the expression profiles of 863 microRNAs were determined by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and this 'miRNome' was validated by quantitative real-time PCR.
Journal ArticleDOI
Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls
Andreas Keller,Petra Leidinger,Julia Lange,Anne Borries,Hannah Schroers,Matthias Scheffler,Hans-Peter Lenhof,Klemens Ruprecht,Eckart Meese +8 more
TL;DR: The miRNA expression profiles in blood cells may serve as a biomarker for MS, and deregulation of mi RNA expression may play a role in the pathogenesis of MS.
Journal ArticleDOI
An estimate of the total number of true human miRNAs.
Julia Alles,Tobias Fehlmann,Ulrike Fischer,Christina Backes,Galata,Marie Minet,Martin Hart,Masood Abu-Halima,Friedrich A. Grässer,Hans-Peter Lenhof,Andreas Keller,Eckart Meese +11 more
TL;DR: The experimentally validated miRNAs will contribute to revising targetomes hypothesized by utilizing falsely annotated miRNA candidates, 1115 of which are currently annotated in miRBase V22.
Journal ArticleDOI
miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments
Andreas Keller,Petra Leidinger,Anne Borries,Anke Wendschlag,Frank Wucherpfennig,Matthias Scheffler,Hanno Huwer,Hans-Peter Lenhof,Eckart Meese +8 more
TL;DR: The findings support the idea that neoplasia may lead to a deregulation of miRNA expression in blood cells of cancer patients compared toBlood cells of healthy individuals and provide evidence that miRNA patterns can be used to detect human cancers from blood cells.