H
Hermann Josef Gröne
Researcher at German Cancer Research Center
Publications - 357
Citations - 25145
Hermann Josef Gröne is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Kidney & Chemokine. The author has an hindex of 82, co-authored 346 publications receiving 23147 citations.
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Journal ArticleDOI
Human Y Chromosome Azoospermia Factors (AZF) Mapped to Different Subregions in Yq11
Peter H. Vogt,A. Edelmann,S. Kirsch,O. Henegariu,P. Hirschmann,F. Kiesewetter,Frank-Michael Köhn,W.-B. Schill,S. Farah,C. Ramos,M. Hartmann,W. Hartschuh,D. Meschede,Hermann M. Behre,A. Castel,Eberhard Nieschlag,Wolfgang Weidner,Hermann Josef Gröne,A. Jung,Wolfgang Engel,Gerhard Haidl +20 more
TL;DR: The presence of not one but three spermatogenesis loci in Yq11 is proposed and that each locus is active during a different phase of male germ cell development.
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Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility
Tim M. Wintermantel,Rebecca Campbell,Robert Porteous,Dagmar Bock,Hermann Josef Gröne,Martin G. Todman,Kenneth S. Korach,Erich Greiner,Cristian A. Pérez,Günther Schütz,Allan E. Herbison +10 more
TL;DR: It is demonstrated that ovulation is driven by estrogen actions upon ERalpha-expressing neuronal afferents to GnRH neurons, located within rostral periventricular regions of the hypothalamus.
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Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah,Manfred Jugold,Fabian Kiessling,Paul Rigby,Mitali Manzur,Hugo H. Marti,Tamer Rabie,Sylvia Kaden,Hermann Josef Gröne,Günter J. Hämmerling,Bernd Arnold,Ruth Ganss +11 more
TL;DR: This is the first demonstration, to the authors' knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumourAngiogenesis.
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Biglycan: A danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors
Andrea Babelova,Kristin Moreth,Kristin Moreth,Wasiliki Tsalastra-Greul,Jinyang Zeng-Brouwers,Jinyang Zeng-Brouwers,Oliver Eickelberg,Marian F. Young,Peter Bruckner,Josef Pfeilschifter,Roland M. Schaefer,Hermann Josef Gröne,Liliana Schaefer +12 more
TL;DR: The results provide evidence for direct activation of the NLRP3 inflammasome by biglycan and describe a fundamental paradigm of how tissue stress or injury is monitored by innate immune receptors detecting the release of the extracellular matrix components and turning such a signal into a robust inflammatory response.
Journal ArticleDOI
Endostatin's antiangiogenic signaling network
Amir Abdollahi,Philip Hahnfeldt,Christian Maercker,Hermann Josef Gröne,Juergen Debus,Wilhelm Ansorge,Judah Folkman,Lynn Hlatky,Peter E. Huber +8 more
TL;DR: It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein, resulting in a unique alignment between the direction of gene regulation andAngiogenic status.