Hermann Josef Gröne

TL;DR: The presence of not one but three spermatogenesis loci in Yq11 is proposed and that each locus is active during a different phase of male germ cell development.

TL;DR: It is demonstrated that ovulation is driven by estrogen actions upon ERalpha-expressing neuronal afferents to GnRH neurons, located within rostral periventricular regions of the hypothalamus.

TL;DR: This is the first demonstration, to the authors' knowledge, of reduced tumour angiogenesis and improved immune therapeutic outcome on loss of a vascular gene function and establishes a previously unrecognized role of G-protein signalling in tumourAngiogenesis.

TL;DR: The results provide evidence for direct activation of the NLRP3 inflammasome by biglycan and describe a fundamental paradigm of how tissue stress or injury is monitored by innate immune receptors detecting the release of the extracellular matrix components and turning such a signal into a robust inflammatory response.

TL;DR: It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein, resulting in a unique alignment between the direction of gene regulation andAngiogenic status.