Irina Lambertz

TL;DR: Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information.

TL;DR: It is shown that although monoallelic loss of Dicer1 does not affect normal retinal development, it dramatically accelerates tumor formation on a retinoblastoma-sensitized background and concludes that Dicer 1 functions as a haploinsufficient tumor suppressor.

TL;DR: It is concluded that acquisition of an illegitimate miR-191 target site causes downregulation of MDM4 expression, thereby significantly delaying ovarian carcinoma progression and tumor-related death and appear to be, at least partly, independent of p53.

TL;DR: Targeted disruption of the p53-MDM2 interaction by the small-molecule MDM2 antagonist nutlin-3 stabilizes p53 and selectively activates the p 53 pathway in neuroblastoma cells with wild-type p53, resulting in a pronounced antiproliferative and cytotoxic effect through induction of G(1) cell cycle arrest and apoptosis.

TL;DR: Nutlin-3 activates the p53 pathway and suppresses tumor growth and reduction in the extent of metastatic disease in this model system of chemoresistant neuroblastoma, provided that wild-type p53 is present.