J
Johannes M.I.H. Gho
Researcher at Utrecht University
Publications - 20
Citations - 948
Johannes M.I.H. Gho is an academic researcher from Utrecht University. The author has contributed to research in topics: Myocardial infarction & Phospholamban. The author has an hindex of 13, co-authored 20 publications receiving 809 citations. Previous affiliations of Johannes M.I.H. Gho include University Medical Center Utrecht.
Papers
More filters
Journal ArticleDOI
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Vinicius Tragante,Michael R. Barnes,Santhi K. Ganesh,Matthew B. Lanktree,Wei Guo,Nora Franceschini,Erin N. Smith,Toby Johnson,Michael V. Holmes,Sandosh Padmanabhan,Konrad J. Karczewski,Berta Almoguera,John Barnard,Jens Baumert,Yen Pei C. Chang,Clara C. Elbers,Martin Farrall,Mary E. Fischer,Tom R. Gaunt,Johannes M.I.H. Gho,Christian Gieger,Anuj Goel,Yan Gong,Aaron Isaacs,Marcus E. Kleber,Irene Mateo Leach,Caitrin W. McDonough,Matthijs F.L. Meijs,Olle Melander,Christopher P. Nelson,Christopher P. Nelson,Ilja M. Nolte,Nathan Pankratz,Thomas S. Price,Jonathan A. Shaffer,Sonia Shah,Maciej Tomaszewski,Peter J. van der Most,Erik P A Van Iperen,Judith M. Vonk,Kate Witkowska,Caroline O. L. Wong,Li Zhang,Amber L. Beitelshees,Gerald S. Berenson,Deepak L. Bhatt,Morris Brown,Amber A. Burt,Rhonda M. Cooper-DeHoff,John M. C. Connell,Karen J. Cruickshanks,Sean P. Curtis,George Davey-Smith,Christian Delles,Ron T. Gansevoort,Xiuqing Guo,Shen Haiqing,Claire E. Hastie,Marten H. Hofker,Marten H. Hofker,G. Kees Hovingh,Daniel Seung Kim,Susan Kirkland,Barbara E.K. Klein,Ronald Klein,Yun Li,Steffi Maiwald,Christopher Newton-Cheh,Eoin O'Brien,N. Charlotte Onland-Moret,Walter Palmas,Afshin Parsa,Brenda W.J.H. Penninx,Mary Pettinger,Ramachandran S. Vasan,Jane E. Ranchalis,Paul M. Ridker,Lynda M. Rose,Peter S. Sever,Daichi Shimbo,Laura Steele,Ronald P. Stolk,Barbara Thorand,Mieke D. Trip,Cornelia M. van Duijn,W M Monique Verschuren,Cisca Wijmenga,Sharon B. Wyatt,J. Hunter Young,Aeilko H. Zwinderman,Connie R. Bezzina,Eric Boerwinkle,Juan P. Casas,Mark J. Caulfield,Aravinda Chakravarti,Daniel I. Chasman,Karina W. Davidson,Pieter A. Doevendans,Anna F. Dominiczak,Garret A. FitzGerald,John G. Gums,Myriam Fornage,Hakon Hakonarson,Indrani Halder,Hans L. Hillege,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,John J.P. Kastelein,Wolfgang Koenig,Meena Kumari,Winfried März,Sarah S. Murray,Jeffrey R. O'Connell,Albertine J. Oldehinkel,James S. Pankow,Daniel J. Rader,Susan Redline,Muredach P. Reilly,Eric E. Schadt,Kandice Kottke-Marchant,Harold Snieder,Michael Snyder,Alice Stanton,Martin D. Tobin,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Nilesh J. Samani,Nilesh J. Samani,Hugh Watkins,Andrew D. Johnson,Alexander P. Reiner,Xiaofeng Zhu,Paul I.W. de Bakker,Daniel Levy,Folkert W. Asselbergs,Folkert W. Asselbergs,Patricia B. Munroe,Brendan J. Keating +139 more
TL;DR: The findings extend the understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification and provide support for a putative role in hypertension of several genes.
Journal ArticleDOI
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
Ioannis Karakikes,Ioannis Karakikes,Francesca Stillitano,Mathieu Nonnenmacher,Christos Tzimas,Despina Sanoudou,Vittavat Termglinchan,Chi Wing Kong,Stephanie N. Rushing,Jens Hansen,Delaine K. Ceholski,Fotis Kolokathis,Dimitrios Th. Kremastinos,Alexandros Katoulis,Lihuan Ren,Ninette Cohen,Johannes M.I.H. Gho,Dimitrios Tsiapras,Aryan Vink,Joseph C. Wu,Folkert W. Asselbergs,Folkert W. Asselbergs,Ronald A. Li,Ronald A. Li,Jean-Sébastien Hulot,Jean-Sébastien Hulot,Evangelia G. Kranias,Evangelia G. Kranias,Roger J. Hajjar +28 more
TL;DR: In this paper, a mutation in the coding region of the phospholamban (PLN) gene (R14del) is identified in families with hereditary heart failure and a number of genetic mutations is associated with cardiomyopathies.
Journal ArticleDOI
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Santhi K. Ganesh,Vinicius Tragante,Wei Guo,Yiran Guo,Matthew B. Lanktree,Erin N. Smith,Toby Johnson,Berta Almoguera Castillo,John Barnard,Jens Baumert,Yen Pei C. Chang,Clara C. Elbers,Martin Farrall,Mary E. Fischer,Nora Franceschini,Tom R. Gaunt,Johannes M.I.H. Gho,Christian Gieger,Yan Gong,Aaron Isaacs,Marcus E. Kleber,Irene Mateo Leach,Caitrin W. McDonough,Matthijs F.L. Meijs,Olle Mellander,Cliona Molony,Ilja M. Nolte,Sandosh Padmanabhan,Tom S. Price,Ramakrishnan Rajagopalan,Jonathan A. Shaffer,Sonia Shah,Haiqing Shen,Nicole Soranzo,Peter J. van der Most,Erik P A Van Iperen,Jessica van Setten,Judith M. Vonk,Li Zhang,Amber L. Beitelshees,Gerald S. Berenson,Deepak L. Bhatt,Jolanda M. A. Boer,Eric Boerwinkle,Ben Burkley,Amber A. Burt,Aravinda Chakravarti,Wei Chen,Rhonda M. Cooper-DeHoff,Sean P. Curtis,Albert W. Dreisbach,David Duggan,Georg Ehret,Richard R. Fabsitz,Myriam Fornage,Ervin R. Fox,Clement E. Furlong,Ron T. Gansevoort,Marten H. Hofker,G. Kees Hovingh,Susan Kirkland,Kandice Kottke-Marchant,Abdullah Kutlar,Andrea Z. LaCroix,Taimour Y. Langaee,Yun Li,Honghuang Lin,Kiang Liu,Steffi Maiwald,Rainer Malik,Gurunathan Murugesan,Christopher Newton-Cheh,Christopher Newton-Cheh,Jeffery R. O'Connell,N. Charlotte Onland-Moret,Willem H. Ouwehand,Walter Palmas,Brenda W.J.H. Penninx,Carl J. Pepine,Mary Pettinger,Joseph F. Polak,Vasan S. Ramachandran,Vasan S. Ramachandran,Jane E. Ranchalis,Susan Redline,Paul M. Ridker,Lynda M. Rose,Hubert Scharnag,Hubert Scharnag,Nicholas J. Schork,Daichi Shimbo,Alan R. Shuldiner,Alan R. Shuldiner,Sathanur R. Srinivasan,Ronald P. Stolk,Herman A. Taylor,Barbara Thorand,Mieke D. Trip,Cornelia M. van Duijn,W. M. Monique Verschuren,Cisca Wijmenga,Bernhard R. Winkelmann,Sharon B. Wyatt,J. Hunter Young,Bernhard O. Boehm,Mark J. Caulfield,Daniel I. Chasman,Karina W. Davidson,Pieter A. Doevendans,Garret A. FitzGerald,John G. Gums,Hakon Hakonarson,Hans L. Hillege,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,John J.P. Kastelein,Wolfgang Koenig,Winfried März,Winfried März,Braxton D. Mitchell,Sarah S. Murray,Albertine J. Oldehinkel,Daniel J. Rader,Muredach P. Reilly,Alexander P. Reiner,Eric E. Schadt,Roy L. Silverstein,Roy L. Silverstein,Harold Snieder,Alice Stanton,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Nilesh J. Samani,Nilesh J. Samani,Andrew D. Johnson,Patricia B. Munroe,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Xiaofeng Zhu,Daniel Levy,Brendan J. Keating,Folkert W. Asselbergs +144 more
TL;DR: Two novel loci associated with BP are identified and multiple previously reported associations are confirmed, extending the understanding of genes involved in BP regulation and some of which may eventually provide new targets for therapeutic intervention.
Journal ArticleDOI
Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people.
Stefan Koudstaal,Stefan Koudstaal,Mar Pujades-Rodriguez,Spiros Denaxas,Johannes M.I.H. Gho,Anoop D. Shah,Ning Yu,Riyaz S. Patel,Chris P Gale,Arno W. Hoes,John G.F. Cleland,Folkert W. Asselbergs,Folkert W. Asselbergs,Harry Hemingway +13 more
TL;DR: The prognosis of patients hospitalized for worsening heart failure is well described, but not that of patients managed solely in non‐acute settings such as primary care or secondary outpatient care, or known in both contexts.
Journal ArticleDOI
Concise Review: Heart Regeneration and the Role of Cardiac Stem Cells
Stefan Koudstaal,Stefan Koudstaal,Roberto Gaetani,Johannes M.I.H. Gho,Frebus J. van Slochteren,Joost P.G. Sluijter,Pieter A. Doevendans,Georgina M. Ellison,Steven A. J. Chamuleau +8 more
TL;DR: The current knowledge of CSCs as the regenerative substrate in the adult heart and their use in preclinical and clinical studies to repair the injured myocardium are summarized.