B
Berta Almoguera Castillo
Researcher at University of Pennsylvania
Publications - 9
Citations - 1958
Berta Almoguera Castillo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 7, co-authored 9 publications receiving 1694 citations. Previous affiliations of Berta Almoguera Castillo include University of Valencia & University of London.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Daniel I. Swerdlow,David Preiss,Karoline Kuchenbaecker,Michael V. Holmes,Jorgen Engmann,Tina Shah,Reecha Sofat,Stefan Stender,Paul C. D. Johnson,Robert A. Scott,Maarten Leusink,Niek Verweij,Stephen J. Sharp,Yiran Guo,Claudia Giambartolomei,Christina Chung,Anne Peasey,Antoinette Amuzu,KaWah Li,Jutta Palmen,Philip N. Howard,Jackie A. Cooper,Fotios Drenos,Yun Li,Gordon D.O. Lowe,John Gallacher,Marlene C. W. Stewart,Ioanna Tzoulaki,Sarah G. Buxbaum,Daphne L. van der A,Nita G. Forouhi,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Ruzena Kubinova,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Romanvan Topor-Madry,Urszula Stepaniak,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,Ulf de Faire,Fabrizio Veglia,Ian Ford,J. Wouter Jukema,Rudi G. J. Westendorp,Gert J. de Borst,Pim A. de Jong,Ale Algra,Wilko Spiering,Anke H. Maitland-van der Zee,Olaf H. Klungel,Anthonius de Boer,Pieter A. Doevendans,Charles B. Eaton,Jennifer G. Robinson,David Duggan,John Kjekshus,John R. Downs,Antonio M. Gotto,Anthony C Keech,Roberto Marchioli,Gianni Tognoni,Peter S. Sever,Neil R Poulter,David D. Waters,Terje R. Pedersen,Pierre Amarenco,Haruo Nakamura,John J.V. McMurray,James Lewsey,Daniel I. Chasman,Paul M. Ridker,Aldo P. Maggioni,Luigi Tavazzi,Kausik K. Ray,Sreenivasa Rao Kondapally Seshasai,JoAnn E. Manson,Jackie F. Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Pamela J. Schreiner,Myriam Fornage,David S. Siscovick,Mary Cushman,Meena Kumari,Nicholas J. Wareham,W M Monique Verschuren,Susan Redline,Sanjay R. Patel,John C. Whittaker,Anders Hamsten,Joseph A.C. Delaney,Caroline Dale,Tom R. Gaunt,Andrew Wong,Diana Kuh,Rebecca Hardy,Sekar Kathiresan,Berta Almoguera Castillo,Pim van der Harst,Eric J. Brunner,Anne Tybjærg-Hansen,Michael Marmot,Ronald M. Krauss,Michael Y. Tsai,Josef Coresh,Ron C. Hoogeveen,Bruce M. Psaty,Leslie A. Lange,Hakon Hakonarson,Frank Dudbridge,Steve E. Humphries,Philippa J. Talmud,Mika Kivimäki,Nicholas J. Timpson,Claudia Langenberg,Folkert W. Asselbergs,Mikhail Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Alexander P. Reiner,Brendan J. Keating,Aroon D. Hingorani,Naveed Sattar +132 more
TL;DR: The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena,Richa Saxena,Clara C. Elbers,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Archana Tare,Berta Almoguera Castillo,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten,Robert A. Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +163 more
TL;DR: Large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to type 2 diabetes risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.
Journal ArticleDOI
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Santhi K. Ganesh,Vinicius Tragante,Wei Guo,Yiran Guo,Matthew B. Lanktree,Erin N. Smith,Toby Johnson,Berta Almoguera Castillo,John Barnard,Jens Baumert,Yen Pei C. Chang,Clara C. Elbers,Martin Farrall,Mary E. Fischer,Nora Franceschini,Tom R. Gaunt,Johannes M.I.H. Gho,Christian Gieger,Yan Gong,Aaron Isaacs,Marcus E. Kleber,Irene Mateo Leach,Caitrin W. McDonough,Matthijs F.L. Meijs,Olle Mellander,Cliona Molony,Ilja M. Nolte,Sandosh Padmanabhan,Tom S. Price,Ramakrishnan Rajagopalan,Jonathan A. Shaffer,Sonia Shah,Haiqing Shen,Nicole Soranzo,Peter J. van der Most,Erik P A Van Iperen,Jessica van Setten,Judith M. Vonk,Li Zhang,Amber L. Beitelshees,Gerald S. Berenson,Deepak L. Bhatt,Jolanda M. A. Boer,Eric Boerwinkle,Ben Burkley,Amber A. Burt,Aravinda Chakravarti,Wei Chen,Rhonda M. Cooper-DeHoff,Sean P. Curtis,Albert W. Dreisbach,David Duggan,Georg Ehret,Richard R. Fabsitz,Myriam Fornage,Ervin R. Fox,Clement E. Furlong,Ron T. Gansevoort,Marten H. Hofker,G. Kees Hovingh,Susan Kirkland,Kandice Kottke-Marchant,Abdullah Kutlar,Andrea Z. LaCroix,Taimour Y. Langaee,Yun Li,Honghuang Lin,Kiang Liu,Steffi Maiwald,Rainer Malik,Gurunathan Murugesan,Christopher Newton-Cheh,Christopher Newton-Cheh,Jeffery R. O'Connell,N. Charlotte Onland-Moret,Willem H. Ouwehand,Walter Palmas,Brenda W.J.H. Penninx,Carl J. Pepine,Mary Pettinger,Joseph F. Polak,Vasan S. Ramachandran,Vasan S. Ramachandran,Jane E. Ranchalis,Susan Redline,Paul M. Ridker,Lynda M. Rose,Hubert Scharnag,Hubert Scharnag,Nicholas J. Schork,Daichi Shimbo,Alan R. Shuldiner,Alan R. Shuldiner,Sathanur R. Srinivasan,Ronald P. Stolk,Herman A. Taylor,Barbara Thorand,Mieke D. Trip,Cornelia M. van Duijn,W. M. Monique Verschuren,Cisca Wijmenga,Bernhard R. Winkelmann,Sharon B. Wyatt,J. Hunter Young,Bernhard O. Boehm,Mark J. Caulfield,Daniel I. Chasman,Karina W. Davidson,Pieter A. Doevendans,Garret A. FitzGerald,John G. Gums,Hakon Hakonarson,Hans L. Hillege,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,John J.P. Kastelein,Wolfgang Koenig,Winfried März,Winfried März,Braxton D. Mitchell,Sarah S. Murray,Albertine J. Oldehinkel,Daniel J. Rader,Muredach P. Reilly,Alexander P. Reiner,Eric E. Schadt,Roy L. Silverstein,Roy L. Silverstein,Harold Snieder,Alice Stanton,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Nilesh J. Samani,Nilesh J. Samani,Andrew D. Johnson,Patricia B. Munroe,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Xiaofeng Zhu,Daniel Levy,Brendan J. Keating,Folkert W. Asselbergs +144 more
TL;DR: Two novel loci associated with BP are identified and multiple previously reported associations are confirmed, extending the understanding of genes involved in BP regulation and some of which may eventually provide new targets for therapeutic intervention.
Journal ArticleDOI
Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations
Clara C. Elbers,Yiran Guo,Vinicius Tragante,Erik P A Van Iperen,Matthew B. Lanktree,Berta Almoguera Castillo,Fang Chen,Lisa R. Yanek,Mary K. Wojczynski,Yun Li,Bart Ferwerda,Christie M. Ballantyne,Sarah G. Buxbaum,Yii-Der Ida Chen,Wei-Min Chen,L. Adrienne Cupples,L. Adrienne Cupples,Mary Cushman,Yanan Duan,David Duggan,Michele K. Evans,Jyotika K. Fernandes,Myriam Fornage,Melissa Garcia,W. Timothy Garvey,Nicole L. Glazer,Felicia Gomez,Tamara B. Harris,Indrani Halder,Virginia J. Howard,Margaux F. Keller,M. Ilyas Kamboh,Charles Kooperberg,Stephen B. Kritchevsky,Andrea Z. LaCroix,Kiang Liu,Yongmei Liu,Kiran Musunuru,Anne B. Newman,N. Charlotte Onland-Moret,Jose M. Ordovas,Inga Peter,Wendy S. Post,Susan Redline,Steven E. Reis,Richa Saxena,Pamela J. Schreiner,Kelly A. Volcik,Xingbin Wang,Salim Yusuf,Alan B. Zonderland,Sonia S. Anand,Diane M. Becker,Bruce M. Psaty,Daniel J. Rader,Alexander P. Reiner,Stephen S. Rich,Jerome I. Rotter,Michèle M. Sale,Michael Y. Tsai,Ingrid B. Borecki,Robert A. Hegele,Sekar Kathiresan,Mike A. Nalls,Herman A. Taylor,Hakon Hakonarson,Suthesh Sivapalaratnam,Folkert W. Asselbergs,Fotios Drenos,James G. Wilson,Brendan J. Keating +70 more
TL;DR: Differences between populations, especially differences in allele frequency, can be leveraged to identify novel signals, as shown by the discovery of ICAM1 and CD36 in the current report.