Justin Thackeray

TL;DR: It is suggested that a dynamic of “formative frustration” is an important aspect for a successful CURE, because iterations can be performed quickly and are inexpensive in both time and money.

TL;DR: Evidence is provided that PLC-γ acts during development at a time when growth ends and differentiation begins, and is important for proper coordination of these two processes, which are critical for appropriate final organ structure and size.

TL;DR: Comparison of intron positions demonstrates that extensive intron loss has occurred during invertebrate evolution and also reveals the presence of conserved introns in both the N- and C-terminal PLC-gamma SH2 domains that are present in SH1 domains in many other genes.

TL;DR: Together with in vitro mutagenesis of the residue affected by the sl(7) mutation, these results confirm the role of Sl in RTK signaling and provide evidence for two genetically separable PLC-gamma-dependent pathways affecting the development of the eye and the wing.

TL;DR: The Gab/dos/Soc-1 proteins form a family of multi-adaptor/scaffolding proteins involved in receptor tyrosine kinase signaling and apart from the PH domain, the proteins show a low level of sequence conservation.