K
Karine Clément
Researcher at University of Paris
Publications - 334
Citations - 38686
Karine Clément is an academic researcher from University of Paris. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 78, co-authored 275 publications receiving 32185 citations. Previous affiliations of Karine Clément include French Institute of Health and Medical Research & Hotel Dieu Hospital.
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Journal ArticleDOI
Richness of human gut microbiome correlates with metabolic markers
Trine Nielsen,Junjie Qin,Edi Prifti,Falk Hildebrand,Gwen Falony,Mathieu Almeida,Manimozhiyan Arumugam,Jean-Michel Batto,Sean Kennedy,Pierre Leonard,Junhua Li,Kristoffer Sølvsten Burgdorf,Niels Grarup,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Ivan Brandslund,Henrik Nielsen,Agnieszka S. Juncker,Marcelo Bertalan,Florence Levenez,Nicolas Pons,Simon Rasmussen,Shinichi Sunagawa,Julien Tap,Sebastian Tims,Erwin G. Zoetendal,Søren Brunak,Karine Clément,Karine Clément,Joël Doré,Michiel Kleerebezem,Karsten Kristiansen,Pierre Renault,Thomas Sicheritz-Pontén,Willem M. de Vos,Willem M. de Vos,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Jeroen Raes,Torben Hansen,Torben Hansen,Peer Bork,Jun Wang,S. Dusko Ehrlich,Oluf Pedersen +46 more
TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Journal ArticleDOI
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Karine Clément,Christian Vaisse,Najiba Lahlou,Sylvie Cabrol,Véronique Pelloux,Dominique Cassuto,Micheline Gourmelen,Christian Dina,Jean Chambaz,Jean-Marc Lacorte,Arnaud Basdevant,Pierre Bougnères,Yves Lebouc,Philippe Froguel,Bernard Guy-Grand +14 more
TL;DR: A homozygous mutation in the human leptin receptor gene results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains, which indicates that leptin is an important physiological regulator of several endocrine functions in humans.
Journal ArticleDOI
Dietary intervention impact on gut microbial gene richness
Aurélie Cotillard,Aurélie Cotillard,Sean Kennedy,Ling Chun Kong,Ling Chun Kong,Edi Prifti,Edi Prifti,Edi Prifti,Nicolas Pons,Mathieu Almeida,Benoit Quinquis,Florence Levenez,Nathalie Galleron,Sophie Gougis,Salwa W. Rizkalla,Salwa W. Rizkalla,Jean-Michel Batto,Pierre Renault,Joël Doré,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Karine Clément,Karine Clément,Stanislav Dusko Ehrlich +24 more
TL;DR: Diet-induced weight-loss and weight-stabilization interventions in a study sample of obese and overweight individuals are conducted and it is reported that individuals with reduced microbial gene richness present more pronounced dys-metabolism and low-grade inflammation.
Journal ArticleDOI
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
Maria Carlota Dao,Amandine Everard,Judith Aron-Wisnewsky,Nataliya Sokolovska,Edi Prifti,Eric O. Verger,Brandon D. Kayser,Florence Levenez,Julien Chilloux,Lesley Hoyles,Marc-Emmanuel Dumas,Salwa W. Rizkalla,Joël Doré,Patrice D. Cani,Karine Clément +14 more
TL;DR: A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults, and the interaction between gut microbiota ecology and A. muc iniphila warrants further investigation.
Journal ArticleDOI
Leptin regulation of bone resorption by the sympathetic nervous system and CART
Florent Elefteriou,Jong Deok Ahn,Shu Takeda,Michael Starbuck,Xiangli Yang,Xiuyun Liu,Hisataka Kondo,William G. Richards,Tony W. Bannon,Masaki Noda,Karine Clément,Christian Vaisse,Gerard Karsenty +12 more
TL;DR: This study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure.