L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
Papers
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Posted ContentDOI
Natural Killer cell division regulates FcεRIγ expression downstream of mTOR activity
Avishai Shemesh,Daniel R. Calabrese,Daniel R. Calabrese,Janice Arakawa-Hoyt,John R. Greenland,John R. Greenland,Lewis L. Lanier +6 more
TL;DR: In this article, an analysis of NK cell subsets in lung transplant patients during rapamycin treatment revealed significantly lower FcRγ levels in the NK cell population, which was associated with low mTORC1/C2 activity and low T-Bet expression.
Patent
Modulacion de nkg2d.
TL;DR: The presente invencion se refiere a metodos y composiciones for tratar y/or prevenir enfermedades autoinmunes y/o inflamatorias as discussed by the authors.
Patent
Anticorps specifiques des antigenes de cellules tueuses naturelles des mammiferes et utilisations correspondantes
TL;DR: In this paper, the mammifere de facon specifique a un antigene de l'enveloppe de cellules tueuses naturelles, concerne egalement des reactifs relatifs a ces anticorps, y compris des proteines purifiees, ainsi que des anticorp specifiques and des acides nucleiques codant l'antigene.
Journal ArticleDOI
Abstract 3602: Mechanisms of CAR T cell dysfunction and identification of transcription factors that drive the exhaustion phenotype
M. Angela Aznar,Charly R. Good,Shunichiro Kuramitsu,Parisa Samareh,Sangya Agarwal,Greg Donahue,Kenichi Ishiyama,Nils Wellhausen,Austin Rennels,Yujie Ma,Lifeng Tian,Sonia Guedan,Katherine A. Alexander,Zhen Zhang,Philipp C. Rommel,Nathan Singh,Karl M. Glastad,Max W. Richardson,Keisuke Watanabe,Janos L. Tanyi,Mark H. O'Hara,Marco Ruella,Simon F. Lacey,Edmund K. Moon,Stephen J. Schuster,Steven M. Albelda,Lewis L. Lanier,Regina M. Young,Shelley L. Berger,Carl H. June +29 more
TL;DR: A robust in vitro model that recapitulates the hallmarks of T cell exhaustion and that facilitated the identification of a gene signature defining CAR dysregulation, a T-to-NK-like-T cell transition as a novel feature of CAR T cell dysfunction and the transcription factors SOX4 and ID3 as key regulators of CART cell exhaustion are developed.