L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Suppression of tumor formation in lymph nodes by L-selectin–mediated natural killer cell recruitment
TL;DR: In tumor-bearing hosts, NK cells are recruited to regional lymph nodes in wild-type mice, but not in mice deficient for L-selectin or L- selectin ligands, indicating that L- Selectin–mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs.
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Natural Killer Cells in Cancer Immunotherapy
TL;DR: As the selective pressures exerted by immunotherapies to augment CD8+ T cell responses may result in loss of MHC class I, NK cells may provide an important fail-safe to eliminate these tumors by their capacity to eliminate tumors that are “missing self.”
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IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors
Jack D. Bui,Leonidas N. Carayannopoulos,Lewis L. Lanier,Wayne M. Yokoyama,Robert D. Schreiber +4 more
TL;DR: This report represents the first demonstration that certain cytokines and specifically the IFNs regulate expression of specific NKG2D ligands on murine tumors and helps to specify the type of immune effector cell populations that participate in host-protective antitumor responses.
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CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
TL;DR: It is shown that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus.
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Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.
TL;DR: These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood.