L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal Article
Analysis of the costimulatory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells.
TL;DR: The notion that NK cell proliferation occurs at different phases of the immune response with the particular cytokine milieu influencing the repertoire of NK cell-secreted cytokines is supported.
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A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562.
TL;DR: The direct activation of highly purified Leu-11+ cells by cocultured with K562 provides an in vitro model with which to study the activation and maturation of human NK cells and suggests that Lee-7 antigen may be expressed late in the differentiation pathway of NK cells.
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Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors
Erin J. Adams,Z. Sean Juo,Rayna Takaki Venook,Martin J. Boulanger,Hisashi Arase,Lewis L. Lanier,K. Christopher Garcia +6 more
TL;DR: Results show that m157 represents a structurally divergent form of MHC class I-like proteins that directly engage Ly49 receptors with appreciable affinity in a noncanonical fashion.
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Cutting Edge: Viral Infection Breaks NK Cell Tolerance to “Missing Self”
Joseph C. Sun,Lewis L. Lanier +1 more
TL;DR: NK cells in mixed wild-type:B2m−/− chimeric mice were initially tolerant of MHC class I-deficient host cells, but this tolerance was gradually lost over time and after mouse CMV infection was rapidly broken, with a pronounced rejection of host B2m/− hematopoietic cells.
Journal Article
Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells.
TL;DR: The capacity of fetal liver progenitors to develop into T cells, in a human/mouse fetal thymic organ culture system, is restricted to an immature subset of CD34+ CD38- cells.