L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal ArticleDOI
Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria
Samuel J. Balin,Matteo Pellegrini,Eynav Klechevsky,Sohui T. Won,David I. Weiss,Aaron Choi,Joshua K. Hakimian,Jing Lu,Maria Teresa Ochoa,Barry R. Bloom,Lewis L. Lanier,Steffen Stenger,Robert L. Modlin +12 more
TL;DR: In this article, the authors found that CD8+ CTLs expressing granzyme B, perforin, and granulysin, as well as activating NK receptor NKG2C, represent a population of "antimicrobial CTL" (amCTLs) capable of T cell receptor (TCR)-dependent and TCR-independent release of cytotoxic granule proteins that mediate antimicrobial activity.
Journal Article
Unusual uniformity of the N-linked oligosaccharides of HLA-A, -B, and -C glycoproteins.
L. D. Barber,T.P. Patel,L Percival,Jenny E. Gumperz,Lewis L. Lanier,Joseph H. Phillips,J C Bigge,M R Wormwald,R B Parekh,Peter Parham +9 more
TL;DR: The uniformity of oligosaccharide structure associated with different HLA-A, -B, and -C products and the relative lack of heterogeneity for any given allotype are unusual features for a mammalian glycoprotein.
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Differential effects of interleukin-3, interleukin-7, interleukin 15, and granulocyte-macrophage colony-stimulating factor in the generation of natural killer and B cells from primitive human fetal liver progenitors
Marcus O. Muench,Laurent Humeau,Bettina W. Paek,Tatsuo Ohkubo,Lewis L. Lanier,Craig T. Albanese,Alicia Bárcena +6 more
TL;DR: Findings indicate a differential regulation of NK and B lymphopoiesis beginning in the early stages of hematopoiedis as exemplified by the distinctive roles of IL-7, IL-15, GM-CSF, and IL-3.
Journal ArticleDOI
Development and function of CD94-deficient natural killer cells.
Mark T. Orr,Jun Wu,Min Fang,Luis J. Sigal,Pieter Spee,Thomas Egebjerg,Erik Dissen,Sigbjørn Fossum,Joseph H. Phillips,Lewis L. Lanier +9 more
TL;DR: The expression of CD94 and its associated NKG2A,NKG2C, and NKG 2E subunits is dispensable for NK cell development, education, and many NK cell functions.
Journal ArticleDOI
Do the terms innate and adaptive immunity create conceptual barriers
Lewis L. Lanier,Joseph C. Sun +1 more
TL;DR: New data showing that innate immune cells can have memory characteristics make a strict binary classification between innate and adaptive immunity meaningless, according to Lewis Lanier and Joseph Sun.