L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Three‐color immunofluorescence analysis of leu antigens on human peripheral blood using two lasers on a fluorescence‐activated cell sorter
Michael R. Loken,Lewis L. Lanier +1 more
TL;DR: A fluorescence-activated cell sorter was modified to quantify simultaneously three immunofluorescence stains on a population of cells, expanding the combinations of antigens that can be studied at any one time and will facilitate the detection and functional analysis of cells in heterogeneous populations.
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An NK-like CAR T cell transition in CAR T cell dysfunction.
Charly R. Good,M. Angela Aznar,Shunichiro Kuramitsu,Parisa Samareh,Sangya Agarwal,Greg Donahue,Kenichi Ishiyama,Nils Wellhausen,Austin K. Rennels,Yujie Ma,Lifeng Tian,Sonia Guedan,Katherine A. Alexander,Zhen Zhang,Philipp C. Rommel,Nathan Singh,Karl M. Glastad,Max W. Richardson,Keisuke Watanabe,Janos L. Tanyi,Mark H. O'Hara,Marco Ruella,Simon F. Lacey,Edmund K. Moon,Stephen J. Schuster,Steven M. Albelda,Lewis L. Lanier,Regina M. Young,Shelley L. Berger,Carl H. June +29 more
TL;DR: In this article, the authors established a robust model of continuous antigen exposure that recapitulates hallmark features of T-cell exhaustion and found that CAR dysregulation is associated with a CD8+ T-to-NK-like Tcell transition.
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Cutting Edge: IL-15-Independent NK Cell Response to Mouse Cytomegalovirus Infection
TL;DR: These findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common γ signaling cytokines during their response against viral infection.
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Inducible Costimulator Costimulates Cytotoxic Activity and IFN-γ Production in Activated Murine NK Cells
TL;DR: Results indicate that NK cell functions are regulated by ICOS, and ICOS-mediated stimulation allowed activated NK cells to kill more efficiently tumor cells expressing MHC class I.
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Natural killer or dendritic : What's in a name?
Hergen Spits,Lewis L. Lanier +1 more
TL;DR: Accumulating data suggest a potential for substantial overlap in phenotypic and functional characteristics between natural killer and dendritic cells.