Lewis L. Lanier

TL;DR: It is shown that NKT cells from adult blood and those from cord blood undergo massive expansion in cell numbers during a 4-wk culture with IL-2, IL-7, phytohemagglutinin, anti- CD3, and anti-CD28 mAbs and newly generated N KT cells may possess the potent ability to develop into IL-4+IFN-γ− NKT2 cells in response to appropriate stimuli and may thereafter acquire the tendency to produce both

TL;DR: It is shown that in normal blood and thymus CD3+, WT31−T cells express neither CD4 nor CD8, which suggests that this population does not represent a major stage of thymic development and may be a distinct lineage of T cells.

TL;DR: Preliminary experiments with neutralizing antibodies to gamma- and alpha-interferons also failed to prevent rIL 2 enhancement of NK cell-mediated cytotoxicity, suggesting that ril 2 does not mediate its effect via release of these cytokines.

TL;DR: Cytotoxicity was also induced in the CD3+, CD16+ population by the presence of anti-CD3 mAb, indicating that cytotoxicity can be triggered by stimulation via theCD3-T cell antigen receptor complex.

TL;DR: Three-color immunofluorescence has been used to determine the co-expression of cell surface antigens on human peripheral blood lymphocytes and Sequential reanalysis of the data directly demonstrated the existence of several unrecognized subpopulations of lymphocytes.