Lewis L. Lanier

TL;DR: TREM‐2 is defined as a receptor family in mouse macrophages and the capacity of these receptors to activate macrophage function through DAP12 is demonstrated and shown to be the mouse orthologues of a recently identified human cDNA.

TL;DR: In this paper, the authors used a mouse model of cytomegalovirus infection to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100fold in the spleen and 1,000-fold in liver after infection.

TL;DR: It is shown that cytotoxicity, but not cytokine production, is triggered by NKG2D in activated NK cells lacking either DAP12 or the Syk family members Syk and ZAP70, and that alternative associations between a receptor and its adaptors may provide a single receptor with a dual 'on-switch', giving mouse NK cells more choices through which to trigger cytot toxicity.

TL;DR: This study has generated more than 200 independently derived human NK cell clones from four individuals of known human histocompatibility leukocyte antigens (HLA) type and found that 70% or more of all NK clones are able to recognize certain HLA-B alleles and many also recognize HLA -A alleles, indicating that Hla-C is not unique in conferring protection against NK lysis.

TL;DR: Past findings leading up to these new discoveries are described, the evidence for and characteristics of NK cell memory are summarized, and the attempts and future challenges to identify these long-lived memory NK cell populations in humans are discussed.