L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal ArticleDOI
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species
Xinfang Huang,Xinfang Huang,Jingjing Li,Stephanie Dorta-Estremera,Stephanie Dorta-Estremera,Jeremy Di Domizio,Scott M. Anthony,Scott M. Anthony,Stephanie S. Watowich,Stephanie S. Watowich,Daniel L. Popkin,Zheng Liu,Philip Brohawn,Yihong Yao,Kimberly S. Schluns,Kimberly S. Schluns,Lewis L. Lanier,Wei Cao,Wei Cao +18 more
TL;DR: The findings suggest a regulatory role for neutrophils in vivo and highlight the importance of an NK-ifN-γ axis downstream of the pDC-IFN-α/β pathway in systemic autoimmunity.
Journal Article
Antigen-Induced Murine B Cell Lymphomas I. Induction and Characterization of CH1 and CH2
TL;DR: Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B10 H-2a H-4b p/Wts, and it is demonstrated that these tumors represent "early" B cells in that they express surface IgM, but do not bear surface delta, gamma, or alpha heavy chains.
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The effects of recombinant interleukin 2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors.
TL;DR: It is demonstrated that resting and rIL-2-activated NK cells had no inhibitory effects on peripheral blood-derived hematopoietic progenitor (HP) cells, and it is suggested that ril- 2-activatedNK cells may be used to purge peripheral blood HP cell preparations of residual tumor cells before hematopolietic reconstitution.
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Critical Residues at the Ly49 Natural Killer Receptor’s Homodimer Interface Determine Functional Recognition of m157, a Mouse Cytomegalovirus MHC Class I-Like Protein
TL;DR: The combined functional and three-dimensional modeling approach suggested that the architecture of the Ly49H dimer is crucial to accessing m157, but not MHC class I, and link Ly49 homodimerization variability to the direct recognition of pathogen products.
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Antigens associated with the activation of murine mononuclear phagocytes in vivo: differential expression of lymphocyte function-associated antigen in the several stages of development.
Gideon Strassmann,Timothy A. Springer,Stephen Haskill,Charles C. Miraglia,Lewis L. Lanier,Dolph O. Adams +5 more
TL;DR: Exposure to radioimmunoassay and flow cytometry data indicate that LFA-1 is selectively expressed on mononuclear phagocytes of the tissues but only on those in the primed and activated stages of development.