L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
Papers
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Journal ArticleDOI
Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
Tsukasa Nabekura,Tsukasa Nabekura,Zhiying Chen,Casey Schroeder,Tae-Ju Park,Eric Vivier,Lewis L. Lanier,Dongfang Liu,Dongfang Liu +8 more
TL;DR: The diminished function of Crk x CrkL–double-deficient NK cells correlated with decreased phosphorylation of STAT4 and STAT1 in response to IL-12 and IFN-α stimulation, respectively, and provide insights into the role ofcrk family proteins in NK cell function and host defense.
Patent
Nucleic acids encoding kp43 protein and antigenic fragments thereof
TL;DR: In this article, the authors provided nucleic acids and polypeptides encoding an NK cell surface antigen from a mammal, as well as antibodies that specifically bind the NK cells surface antigen.
Patent
Identification of NK cells and cytotoxic T lymphocytes
TL;DR: In this article, a method for distinguishing between NK cells and T lymphocytes is provided, which comprises contacting a sample containing lymphocytes with a first rea-gent comprising anti-CD3 and a first detectable label and a second reagent comprising a mixture of anti-CB16 and anti-GP160 (Leu-19) both labeled with a second de-tectable label, and identifying cells that react with the reagents.
Journal ArticleDOI
Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories
Yapeng Su,Daniel Chen,Christopher Lausted,Dan Yuan,Jongchan Choi,Cheng Dai,Valentin Voillet,Kelsey Scherler,Pamela Troisch,Venkata R Duvvuri,Priyanka Baloni,Guangrong Qin,Brett Smith,Sergey A. Kornilov,Clifford Rostomily,Alexander M. Xu,Jing Li,Shen Dong,Alissa C. Rothchild,Jing Zhou,Kim Murray,Rick Edmark,Sunga Hong,Lesley Jones,Yong Zhou,Ryan Roper,Sean Mackay,Shane O'Mahony,Christopher R. Dale,Julie A. Wallick,Heather A. Algren,Zager A. Michael,Andrew T. Magis,Wei Wei,Nathan D. Price,Sui Huang,Naeha Subramanian,Kai Wang,Jennifer Hadlock,Leroy Hood,Alan Aderem,Jeffrey A. Bluestone,Lewis L. Lanier,Phil Greenberg,Raphael Gottardo,Mark M. Davis,Jason D Goldman,James R. Heath +47 more
TL;DR: A comprehensive immune response map spanning 454 proteins and 847 metabolites in plasma integrated with single-cell multi-omic assays of 221,748 PBMCs is presented, revealing novel cellular subpopulations that may be features of severe COVID-19 infection.