L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
Papers
More filters
Journal Article
Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.
Stuart G. Tangye,Sasha Lazetic,Erica Woollatt,Grant R. Sutherland,Lewis L. Lanier,Joseph H. Phillips +5 more
TL;DR: The results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM, but also other cell surface molecules that utilize SAP as a signaling adaptor protein.
Journal ArticleDOI
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Kouetsu Ogasawara,Jessica A. Hamerman,Lauren I.R. Ehrlich,Hélène Bour-Jordan,Pere Santamaria,Jeffrey A. Bluestone,Lewis L. Lanier +6 more
TL;DR: The authors showed that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancresis express NKG2D.
Journal ArticleDOI
T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
Craig N. Jenne,Anselm Enders,Richard Rivera,Susan R. Watson,Alexander J. Bankovich,João Pereira,Ying Xu,Carla M. Roots,Joshua N. Beilke,Arnob Banerjee,Steven L. Reiner,Sara A. Miller,Amy S. Weinmann,Christopher C. Goodnow,Lewis L. Lanier,Jason G. Cyster,Jerold Chun +16 more
TL;DR: Findings identify S1P5 as a T-bet–induced gene that is required for NK cell egress from LNs and BM, and suggests a role for S1p in BM egress.
Journal ArticleDOI
NK cells in innate immunity.
TL;DR: These findings, as well as advances in understanding NK cell development and homeostasis, indicate that NK cell biology is more sophisticated than previously appreciated.
Journal ArticleDOI
NKG2D-mediated Natural Killer Cell Protection Against Cytomegalovirus Is Impaired by Viral gp40 Modulation of Retinoic Acid Early Inducible 1 Gene Molecules
Melissa B. Lodoen,Kouetsu Ogasawara,Jessica A. Hamerman,Hisashi Arase,Jeffrey P. Houchins,Edward S. Mocarski,Lewis L. Lanier +6 more
TL;DR: It is demonstrated that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1–NKG2D interaction.