L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients
Courtney A. Crane,Kathryn Austgen,Kristen Haberthur,Carly Hofmann,Kara White Moyes,Lia Avanesyan,Lawrence Fong,Michael J. Campbell,Stewart Cooper,Scott A. Oakes,Andrew T. Parsa,Lewis L. Lanier +11 more
TL;DR: It is demonstrated that lactate dehydrogenase (LDH) isoform 5 secreted by glioblastoma cells induces NKG2D ligands on monocytes isolated from healthy individuals, which reveals a previously unidentified immune evasion strategy.
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BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells.
Wei Cao,Li Zhang,David B. Rosen,Laura Bover,Gokuran Watanabe,Musheng Bao,Lewis L. Lanier,Yong-Jun Liu +7 more
TL;DR: It is demonstrated here that BDCA2 forms a complex with the transmembrane adapter FcɛRIγ, which activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs.
Journal Article
CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.
TL;DR: Recognition of HLA-G by NK cells was prevented in the presence of anti-CD94 mAb, implicating CD94/NKG2 as the predominant inhibitory NK cell receptor for Hla-G used by decidual NK cells.
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Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell–mediated innate resistance to cytomegalovirus infection
Marie-Pierre Desrosiers,Agnieszka Kielczewska,J C. Loredo-Osti,Sonia Girard Adam,Andrew P. Makrigiannis,Suzanne Lemieux,Trung H.M. Pham,Melissa B. Lodoen,Kenneth Morgan,Lewis L. Lanier,Silvia M. Vidal +10 more
TL;DR: It is found that natural killer cell–activating receptor Ly49P specifically recognized MCMV-infected cells, dependent on the presence of the H2 k haplotype, and binding was blocked using antibodies to H-2Dk but not antibodies toH-2Kk.
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Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation.
William H. Carr,David B. Rosen,Hisashi Arase,Douglas F. Nixon,Jakob Michaëlsson,Lewis L. Lanier +5 more
TL;DR: It is demonstrated that KIR3DS1 is expressed on peripheral blood NK cells and triggers both cytotoxicity and IFN-γ production and this may be peptide dependent.