L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal ArticleDOI
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
Lewis L. Lanier,Nancy A. Federspiel,Joyce J. Ruitenberg,Joseph H. Phillips,James P. Allison,Dan R. Littman,Arthur Weiss +6 more
TL;DR: The expression of a CD3-associated disulfide-linked heterodimer on CD3+,4-,8- T cell lines established from normal, adult peripheral blood contrasts with prior reports describing a CD2-associated non-disulfides-linkedheterodimer, and is proposed that this discrepancy may be explained by preferential usage of the two C gamma genes in T lymphocytes.
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The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns.
Markus Uhrberg,Nicholas Valiante,Neil Thomas Young,Lewis L. Lanier,Joseph H. Phillips,Peter Parham +5 more
TL;DR: Overall, αβ T cells exhibited a distinct pattern of NKR expression different from that of γδ T and NK cells, which expressed highly similar NKR repertoires.
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Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection
Tsukasa Nabekura,Minoru Kanaya,Akira Shibuya,Guo Fu,Nicholas R. J. Gascoigne,Lewis L. Lanier +5 more
TL;DR: The role of the costimulatory molecule DNAM-1 in the differentiation of NK cells in a mouse model of cytomegalovirus (MCMV) infection is investigated and cooperative signaling through DNAM -1 and Ly49H are required for NK cell-mediated host defense against MCMV infection.
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Face off--the interplay between activating and inhibitory immune receptors.
TL;DR: The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors, and studies are beginning to reveal how these 'paired receptors' control immune functions.
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Turning on Natural Killer Cells
TL;DR: NK cells preferentially recognize and kill cells that lack expression of MHC class I and inhibitory receptors expressing immunoreceptor tyrosine-based inhibition motifs prevent NK cells from harming tissues expressing normal levels of classical or nonclassical MHCclass I.