L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
Papers
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Journal ArticleDOI
Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
Tsukasa Nabekura,Lewis L. Lanier +1 more
TL;DR: Comparison of the activation and differentiation of Ly49D-bearing NK cells in mice lacking or expressing H-2D(d), the cognate MHC class I ligand of Ly 49D shows that activating receptors for self-MHCclass I modulate the differentiation of MCMV-specific NK cells and are beneficial for host defense against MCVV infection.
Patent
Differentiation of natural killer cell subpopulations of cells
Lewis L. Lanier,Noel L. Warner +1 more
TL;DR: In this article, a method for distinguishing multiple subpopulations of a cell sample was proposed, whereby human natural killer cells sub-populations can be monitored by using two monoclonal antibodies identified as anti-Leu-7 and anti-leu-11.
Journal ArticleDOI
Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury
Daniel R Calabrese,Daniel R Calabrese,Emily Aminian,Beñat Mallavia,Fengchun Liu,Simon J. Cleary,Oscar A. Aguilar,Ping Wang,Jonathan P. Singer,Steven R. Hays,Jeffrey A. Golden,Jasleen Kukreja,Daniel T. Dugger,Mary C. Nakamura,Mary C. Nakamura,Lewis L. Lanier,Mark R. Looney,John R. Greenland,John R. Greenland +18 more
TL;DR: A causal role for recipient peripheral NK cells in pulmonary IRI via NK cell NKG2D receptor ligation is supported and Therapies targeting NK cells may hold promise in acute lung injury.
Patent
Method for monitoring activated cell subpopulations
TL;DR: In this paper, a method of distinguishing multiple subpopulations of a cell sample was proposed, whereby resting and activated human natural killer cells sub-populations can be monitored using two monoclonal antibodies identified as antiLeu 11 and anti-DR (or anti-Leu 10 or anti-transferrin receptor).
Journal ArticleDOI
CD28/CTLA-4 ligands: the gene encoding CD86 (B70/B7.2) maps to the same region as CD80 (B7/B7.1) gene in human chromosome 3q13-q23.
TL;DR: The assignment of the CD86 gene to human chromosome 3 is reported here using Southern blot analysis on a panel of hamster × human somatic cell hybrid genomic DNA and fluorescence hybridization in situ on metaphase chromosomes coupled with GTG banding confirmed this assignment and localized it to 3q13‐q23 region.