L
Lewis L. Lanier
Researcher at University of California, San Francisco
Publications - 576
Citations - 93495
Lewis L. Lanier is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Interleukin 21 & Natural killer cell. The author has an hindex of 159, co-authored 554 publications receiving 86677 citations. Previous affiliations of Lewis L. Lanier include University of Rome Tor Vergata & Cancer Research Institute.
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Journal ArticleDOI
Lymphokine-activated killer cell activity: Characteristics of effector cells and their progenitors in blood and spleen
Ronald B. Herberman,John C. Hiserodt,N L Vujanovic,Charles M. Balch,Eva Lotzová,Reinder Bolhuis,Sidney H. Golub,Lewis L. Lanier,Joseph H. Phillips,Carlo Riccardi,Jerome Ritz,Angela Santoni,Reinholdt E. Schmidt,Atsushi Uchida +13 more
TL;DR: What is known of the characteristics of LAK cell activity is reviewed and it is concluded that most of it can be attributed to natural killer cells stimulated by IL-2.
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Viral modulation of NK cell immunity.
TL;DR: The unique relationship that exists between NK cells and viruses, with a focus on herpesviruses is reviewed, highlighting the role thatNK cells play in innate immune responses against viruses.
Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor 1
David B. Rosen,Jayaram Bettadapura,Mohammed Alsharifi,Porunelloor A. Mathew,Hilary S. Warren,Lewis L. Lanier +5 more
TL;DR: It is demonstrated that the lectin-like transcript-1 (LLT1) is a physiologic ligand for NKR-P1A, a C-type lectin receptors present on NK cells and subsets of T cells.
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Plasmacytoid dendritic cell–specific receptor ILT7–FcεRIγ inhibits Toll-like receptor–induced interferon production
Wei Cao,David B. Rosen,Tomoki Ito,Laura Bover,Musheng Bao,Gokuran Watanabe,Zhengbin Yao,Li-Li Zhang,Lewis L. Lanier,Yong-Jun Liu +9 more
TL;DR: It is demonstrated here that ILT7 protein associates with the signal adapter protein FcɛRIγ to form a receptor complex that negatively regulates the innate immune functions of human pDCs.
Journal ArticleDOI
Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule
Kazuko Shibuya,Lewis L. Lanier,Joseph H. Phillips,Hans D. Ochs,Kenji Shimizu,Eiichi Nakayama,Hiromitsu Nakauchi,Akira Shibuya,Akira Shibuya +8 more
TL;DR: It is demonstrated that genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM- 1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM -1 and L FA-1.